Cefazolin
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Cefazolin 속성
- 녹는점
- 198-200 C
- 밀도
- 2.01±0.1 g/cm3(Predicted)
- 저장 조건
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- 용해도
- DMSO(약간 용해됨), 메탄올(매우 소량, 가열)
- 산도 계수 (pKa)
- pKa 2.15 (Uncertain)
- 물리적 상태
- Solid
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
- CAS 데이터베이스
- 25953-19-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 20/21/22-36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
HS 번호 | 2941906000 | ||
유해 물질 데이터 | 25953-19-9(Hazardous Substances Data) | ||
독성 | mouse,LD50,intramuscular,4gm/kg (4000mg/kg),Byoin Yakugaku. Hospital Pharmacology. Vol. 3, Pg. 220, 1978. | ||
기존화학 물질 | KE-25357 |
그림문자(GHS): |
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Cefazolin C화학적 특성, 용도, 생산
개요
Cefazolin has the natural acetyl side chain at C-3 replaced by a thio-linked thiadiazole ring. Although this group is an activating leaving group, the moiety is not subject to the inactivating host hydrolysis reaction that characterizes cephapirin. At C-7, it possesses a tetrazoylmethylene unit. Cefazolin is less irritating on injection than its cohort in this generation of drugs and has a longer half-life than cephapirin. Its dosing should be reduced in the presence of renal impairment. It is comparatively unstable and should be protected from heat and light.화학적 성질
needles용도
Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.정의
ChEBI: A cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.Antimicrobial activity
Enterobacter, Klebsiella, Providencia, Serratia spp. and Pr. vulgaris are all resistant. B. fragilis is resistant, but other anaerobes are susceptible.Pharmacokinetics
DistributionThe volume of distribution is the smallest of the cephalosporins in group 1, perhaps an indication of relative confinement to the plasma space. It crosses inflamed synovial membranes, but the levels achieved are well below those of the simultaneous serum levels and entry to the CSF is poor. In patients receiving 10 mg/kg by intravenous bolus, mean concentrations in cancellous bone were 3.0 mg/kg when the mean serum concentration was 33 mg/L, giving a bone:serum ratio of 0.09. Some crosses the placenta, but the concentrations found in the fetus and membranes are low.
Metabolism and excretion
It is not metabolized. Around 60% of the dose is excreted in the urine within the first 6 h, producing concentrations in excess of 1 g/L. Excretion is depressed by probenecid. The renal clearance is around 65 mL/min and declines in renal failure, when the half-life may rise to 40 h, although levels in the urine sufficient to inhibit most urinary pathogens are still found. It is moderately well removed by hemodialysis and less well by peritoneal dialysis.
Levels sufficient to inhibit a number of enteric organisms likely to infect the biliary tract are found in T-tube bile (17–31 mg/L after a 1 g intravenous dose), but this is principally due to the high serum levels of the drug and the total amounts excreted via the bile are small.
Clinical Use
Cefazolin has been widely used in surgical prophylaxis, especially in biliary tract (because of the moderately high concentrations achieved in bile), orthopedic, cardiac and gynecological surgery.부작용
Side effects are those common to other cephalosporins ,including rare bleeding disorders and encephalopathy in patients in whom impaired excretion or direct instillation leads to very high CSF levels. Neutropenia has been described and hypoprothrombinemic bleeding has been attributed to the side chain.Cefazolin 준비 용품 및 원자재
원자재
1-페닐-1H-테트라졸-5-티올
5-메틸-1,3,4-티아디아졸-2-티올
1H-테트라졸-1-아세트산
7-(5-아미노-5-카르복시발레라미도)세팔로스포란산
1H-테트라졸-1-아세틸염화물
수산화나트륨
5-메틸-1,3-벤젠디아세토니트릴
7-아미노세팔로스포란산
중탄산나트륨(중조)
준비 용품
Cefazolin 공급 업체
글로벌( 210)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21677 | 55 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
Cefazolin 관련 검색:
메틸파라벤 3-메틸-1-페닐-2-피라졸린-5-온 메틸 바이올렛 (2B) 아크릴산메틸 아세트산 메틸 메틸알콜 세프타졸린 나트륨 이염화파라콰트 쿠레톡심메틸 5-메틸-1,3,4-티아디아졸-2-티올 아세트아미노펜 아세토나이트릴 7-아미노-3-클로로메틸-3-세펨- 4-카본산 p-메톡시벤질에스테르
7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic Acid
Naphazoline hydrochloride
2,1,3-Benzothiadiazole
Oxymetazoline
Acetylcholine