PANGAMIC ACID
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PANGAMIC ACID 속성
안전
PANGAMIC ACID C화학적 특성, 용도, 생산
개요
Pangamic acid, also called pangamate, is the name given to the chemical compound described as d-glucono dimethyl amino acetic acid, initially promoted by Ernst T. Krebs, Sr. and his son Ernst T. Krebs, Jr. as a medicinal compound for use in treatment of a wide range of diseases. They also termed this chemical "Vitamin B15", though it is not a true vitamin, has no nutritional value, has no known use in the treatment of any disease and has been called a "quack remedy." Although a number of compounds labelled "pangamic acid" have been studied or sold, no chemical compound, including those claimed by the Krebses to be pangamic acid, has been scientifically verified to have the characteristics that defined the original description of the compound.화학적 성질
Pangamic acid is the name given to the chemical compound with the empirical formula C10H19O8N and a molecular weight of 281 which appeared to be an ester derived from d-gluconic acid and dimethylglycine. In 1943, the Krebses applied for a patent for a process for extracting this chemical compound which they reported had been previously isolated from apricot seeds, and received the patent in 1949. A 1951 paper by the Krebses reported the first isolation of this compound using this patented process, but did not include enough information to confirm that this compound was actually isolated. In 1955, the Krebses received a patent for another synthesizing process for "N-substituted glycine esters of gluconic acid," but the patent contained no supporting data to confirm the process was able to synthesize compounds described by the patent, including pangamic acid.Subsequent attempts at synthesizing this ester by other researchers found Krebs' purported methods of producing pangamic acid were not reproducible, and research into pangamic acid have focused on compounds of various chemical compositions. A review noted that of all the chemicals described in research about pangamic acid, "[n]ot a single product labeled "pangamate" or "B15" has been established in a scientifically verifiable manner to conform to the empiric formula" described by the Krebses. Analysis of a sample of a compound called "pangamic acid" which was provided by a co-worker of the Krebses in the 1950s showed only lactose upon further evaluation by nuclear magnetic resonance spectroscopy. Thus, "pangamic acid" is more a label used to describe one of any number of chemical compounds rather than a particular substance.
Chemical compounds sold as "pangamic acid" for medicinal purposes have also had various chemical compositions, and suppliers of "pangamic acid" have regularly changed the chemical composition of the compounds sold under this label. .
Safety
Positive results from mutagenicity analysis via the Ames test of compounds commonly found in preparations labelled "pangamic acid" including diisopropylamine dichloroacetate, diisopropylamine, dichloroacetate, as well as dimethylglycine mixed with sodium nitrite suggests there may be concern for the development of cancer with the use of these substances.PANGAMIC ACID 준비 용품 및 원자재
원자재
준비 용품
PANGAMIC ACID 공급 업체
글로벌( 37)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24330 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
info@afinechem.com | China | 15395 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9320 | 58 |
Zhuoer Chemical Co., Ltd | 02120970332; +8613524231522 |
sales@zhuoerchem.com | China | 2905 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 |
sales@senfeida.com | China | 23053 | 58 |
PANGAMIC ACID 관련 검색:
아미그달린 시아노코발아민 트랜스-레티날 디메틸글리신에틸에스테르 디에틸아미노에톡시에탄올
Nicotinic acid
FERRIC GLYCEROPHOSPHATE
PANGAMIC ACID
GLYCINE N-BUTYL ESTER HYDROCHLORIDE
GLYCINE N-PROPYL ESTER HYDROCHLORIDE
N-(2-METHOXYETHYL)ISOPROPYLAMINE
4-Acetylphenylboronic acid
(ISOPROPYLAMINO)ACETIC ACID
ETHYL N,N-DIETHYLAMINOACETATE
N-ISOPROPYL-N-METHYLGLYCINE
N,N-DIETHYLGLYCINE METHYL ESTER
DIISOPROPYLAMINO-ACETIC ACID
N,N-DIMETHYL(2-HYDROXYETHYL)AMMONIUM 2-HYDROXYACETATE