라놀린

라놀린 속성

라놀린 MSDS

Lanolin

라놀린 C화학적 특성, 용도, 생산

존재

면양의 털에서 추출한 기름. 양털 세척시 폐액에서 원심분리하거나 용제추출하여 얻는 양모지가 탈수라놀린이며 이것을 정제한 것이 정제라놀린이다.

개요

정제라놀린은 옅은 황색 연고유사물질로 무취이다. 40℃에서 용융하고 에테르, 클로로포름, 열알코올에 잘 녹으며,물을 2배 더 첨가하더라도 연고모양의 조도(稠度)를 유지한다. 정제라놀린은 지방산과 알코올류가 약 절반씩 포함되어 있는 납모양물질이다.

용도

의약용, 화장품에 사용한다.

화학적 성질

Lanolin is a pale yellow-colored, unctuous, waxy substance with a faint, characteristic odor. Melted lanolin is a clear or almost clear, yellow liquid.

용도

lanolin (hydrogenated) is a lanolin derivative.

정의

lanolin: An emulsion of purified wool fat in water, containing cholesteroland certain terpene alcoholsand esters. It is used in cosmetics.

생산 방법

Lanolin is a naturally occurring wax-like material obtained from the wool of sheep, Ovis aries Linne′ (Fam. Bovidae).
Crude lanolin is saponified with a weak alkali and the resultant saponified fat emulsion is centrifuged to remove the aqueous phase. The aqueous phase contains a soap solution from which, on standing, a layer of partially purified lanolin separates. This material is then further refined by treatment with calcium chloride, followed by fusion with unslaked lime to dehydrate the lanolin. The lanolin is finally extracted with acetone and the solvent is removed by distillation.

Pharmaceutical Applications

Lanolin is widely used in topical pharmaceutical formulations and cosmetics.
Lanolin may be used as a hydrophobic vehicle and in the preparation of water-in-oil creams and ointments. When mixed with suitable vegetable oils or with soft paraffin, it produces emollient creams that penetrate the skin and hence facilitate the absorption of drugs. Lanolin mixes with about twice its own weight of water, without separation, to produce stable emulsions that do not readily become rancid on storage.

부작용

Most emollients can be used safely and effectively without side effects. However, burning, stinging, redness or irritation may occur. Rare and very serious allergic reactions are abnormal changes in the skin (e.g., whitening/softening/wetness from over-moisturisation), rashes, itching/swelling (especially on the face/tongue/throat), severe dizziness, and difficulty breathing. If any discomfort occurs, contact your doctor immediately.

Safety

Lanolin is widely used in cosmetics and a variety of topical pharmaceutical formulations.
Although generally regarded as a nontoxic and nonirritant material, lanolin and lanolin derivatives are associated with skin hypersensitivity reactions, and the use of lanolin in subjects with known sensitivity should be avoided. Other reports suggest that ‘sensitivity’ arises from false positives in patch testing.However, skin hypersensitivity is relatively uncommon; the incidence of hypersensitivity to lanolin in the general population is estimated to be around 5 per million.
Sensitivity is thought to be associated with the content of free fatty alcohols present in lanolin products rather than the total alcohol content.The safety of pesticide residues in lanolin products has also been of concern. However, highly refined ‘hypoallergenic’ grades of lanolin and grades with low pesticide residues are commercially available.

저장

Lanolin may gradually undergo autoxidation during storage. To inhibit this process, the inclusion of butylated hydroxytoluene is permitted as an antioxidant. Exposure to excessive or prolonged heating may cause anhydrous lanolin to darken in color and develop a strong rancidlike odor. However, lanolin may be sterilized by dry heat at 150°C. Ophthalmic ointments containing lanolin may be sterilized by filtration or by exposure to gamma irradiation.

비 호환성

Lanolin may contain prooxidants, which may affect the stability of certain active drugs.

Regulatory Status

Included in the FDA Inactive Ingredients Database (ophthalmic, otic, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

라놀린 준비 용품 및 원자재

원자재

준비 용품

라놀린 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2986	55
Hubei Aumei New Material Co., Ltd.	+86-027-87366298 +8615927270571	tianyi@skbiology.cn	China	282	58
Lewoo Pharmatech(Shanghai)Co.,Ltd	+86-15800805830 +86-15800805830	miao@lewoopharma.com.cn	China	184	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3010	58
Aurora Industry Co., Ltd.	+86-13591747876 +86-13591747876	alex1_auco@126.com	China	277	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8812	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Yime New Material Technology Co., Ltd.	+86-66697723 +86-17703311139	admin@china-yime.com	China	563	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	998	58

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