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DDD85646

DDD85646 구조식 이미지

카스 번호:: 1215010-55-1

상품명:: DDD85646

동의어(영문):: DDD85646;DDD 85646 (DDD85646);DDD85646 Hydrochloride;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite

CBNumber:: CB34666388

분자식:: C21H24Cl2N6O2S

포뮬러 무게:: 495.43

MOL 파일:: 1215010-55-1.mol

속성

안전

용도

공급 업체 34

DDD85646 속성

녹는점: >215°C (dec.)

끓는 점: 684.3±65.0 °C(Predicted)

밀도: 1.48±0.1 g/cm3(Predicted)

저장 조건: Hygroscopic, -20°C Freezer, Under inert atmosphere

용해도: DMSO(약간 용해됨, 가열), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 7.04±0.50(Predicted)

색상: 황백색에서 노란색까지

안전

DDD85646 C화학적 특성, 용도, 생산

개요

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent K_i value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC₅₀ = 6.9 μM).

용도

DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT).

DDD85646 준비 용품 및 원자재

원자재

준비 용품

DDD85646 공급 업체

글로벌( 34)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4264	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2981	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9887	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58