인간NEUROTROPHIN-3

인간NEUROTROPHIN-3
인간NEUROTROPHIN-3 구조식 이미지
카스 번호:
130939-66-1
한글명:
인간NEUROTROPHIN-3
동의어(한글):
인간NEUROTROPHIN-3
상품명:
NEUROTROPHIN-3, HUMAN
동의어(영문):
NT-3;HDNF;NTF3;HGNF;NGF-2;RHNT-3;HUMAN HGNF;NT-3 HUMAN;HUMAN NT-3;RAGE human
CBNumber:
CB3489307
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

인간NEUROTROPHIN-3 속성

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인간NEUROTROPHIN-3 C화학적 특성, 용도, 생산

일반 설명

NT-3 (neurotrophin 3) is a neurotrophic factor structurally related to β-NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6kDa polypeptide monomers (240 total amino acid residues). The amino acid sequences of human, murine and rat NT-3 are identical.

Biochem/physiol Actions

NT-3 (neurotrophin 3) promotes the growth and survival of nerve and glial cells. It is associated with neuroprotection and polymorphisms in the gene are associated with risk to Alzheimer′s disease. It is also linked with attention-deficit/hyperactivity disorder (ADHD) and mood disorders. NT-3 enhances the metastatic proliferation of breast cancer cells in the brain.

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