아나바신
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아나바신 속성
- 녹는점
- 9 °C
- 끓는 점
- 270 °C
- 밀도
- 1.05 g/mL at 25 °C(lit.)
- 굴절률
- 1.5440
- 인화점
- 93 °C
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- H2O: 10 mg/mL
- 산도 계수 (pKa)
- 8.98±0.10(Predicted)
- 물리적 상태
- 액체
- 색상
- 무색~황색
- Merck
- 14,619
- BRN
- 82639
- InChIKey
- MTXSIJUGVMTTMU-UHFFFAOYSA-N
- LogP
- 0.852 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 23/24/25-36/37/38-25-20/21/22-51/53-27/28 | ||
안전지침서 | 36/37/39-45-26-36-57-27/28-23-20 | ||
유엔번호(UN No.) | UN 3140 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | BV4375000 | ||
위험 참고 사항 | Toxic | ||
위험 등급 | 6.1 | ||
포장분류 | I | ||
HS 번호 | 29339900 | ||
유해화학물질 필터링 | 97-1-155 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 아나바신과 그 염류 및 그 중 하나를 1% 이상 함유한 혼합물 |
아나바신 C화학적 특성, 용도, 생산
개요
Anatabine is an alkaloid found in the root, fibrous roots, or bark of Alangium chinense (Lour) Harms. The herb was recorded in “Jianyi Bencao,” “Bencao Gangmu Shiyi,” and “Zhi Wu Ming Shi Tu Kao.” Alangium chinense is widely distributed in the east and south of China. It is also called “Bailongxu” in Shaanxi, Yunnan, and Guizhou provinces, “Baijintiao” in Guangxi province, and “Bajiaowutong,” “Bajiaojinpan,” or “Laolongxu” in Jiangxi and Hubei provinces. This plant is commonly used as a traditional Chinese medicine. The Alangium species includes more than 30 plants which are distributed in Asia, Oceania, and Africa. Nine of these plants are distributed in China. The root and the stem parts of Alangium plants are toxic.화학적 성질
Colourless Oil물리적 성질
Appearance: Colorless to yellow liquid. Solubility: Soluble in water and common organic solvents. Boiling point: 110?°C. Refractive index: 1.5418. Density: 1.0516?g cm?3.역사
Alangium chinense contains alkaloids, sugars, saponins, steroids, triterpenes, anthraquinones and their glycosides, and other ingredients. In 1974, dl-anabasine was isolated from the fibrous roots of Alangium chinense . Four isoquinoline alkaloids including two new alkaloids (?)-10-O-dimethyl-eugenol base and 10-O-dimethyl-eugenol base were isolated. P-amyrin acetate, triacontanol, and β-sitosterol were then found in its leaves . Seven glycosides were isolated from the water-soluble fraction of dried leaves of Alangium chinense, and eight glycosides were also isolated from the n-butanol soluble part . Three new lignincompounds including 2-O-(β-apio-furanosyl)-β-glucoside, E ferulic acid ester, and Z ferulic acid ester were extracted from Alangium chinense, and their structures were determined. Nakamoto et?al. extracted 7-O-acetylmaleic acid from Alangium chinense and determined the structure. There are also long-chain fatty acids and short-chain alkanes in Alangium chinense leaves. The volatile oil was then analyzed, and 59 components are identified by GC-MS.?The total alkaloid content in the Alangium chinense was found to be fibrous root > fine root > coarse root > branch wood > leaf.용도
A nicotinic receptor agonist정의
ChEBI: A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3.일반 설명
Anabasine inhibited androstenedione conversion to estrogen in a dose-dependent manner.Pharmacology
Alangium plants have wide pharmacological effects including muscle relaxation, central inhibition, anticancer, antibacterial, and so on. The “Jisong-II” injection has presynaptic and postsynaptic effects on the neuromuscular junction, and it acts as noncompetitive muscular relaxant . In 1979, the respiratory suppression experiments showed that Alangium chinense is a central nervous system depressant . The extract of Alangium chinense significantly inhibits the growth of P388 lymphoblastic leukemia and Gardner lymphosarcoma in mice, but it has no effect on Gross virus-induced leukemia, Warner myelomonocytic leukemia, and B16 melanoma . Another study reported that the anabasine could excite respiratory similar to nicotine and lobeline. Anabasine also induces high blood pressure and bradycardia. The components in the Alangium chinense extract can bind to the M, 5-HT and dopamine receptors indicating that Alangium chinense affects the central nervous system.Clinical Use
The Alangium chinense was used for treating rheumatoid arthritis.아나바신 준비 용품 및 원자재
원자재
준비 용품
아나바신 공급 업체
글로벌( 143)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 873 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29890 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7621 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3777 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21149 | 58 |
아나바신 관련 검색:
4-피페레리디노피리딘 아나바신 아나바신
(R,S)-N-NITROSOANABASINE
(5-Bromopicolinoyl)piperidine, (5-Bromopyridin-2-yl)(piperidin-1-yl)methanone
1-(5-Bromopyrimidin-2-yl)piperidine-3-carboxylic acid
DL-ANABASINE Hydrochloride
1-(3-CHLOROPYRIDIN-2-YL)PIPERIDIN-4-AMINE
(R,S)-ANABASINE,DL-ANABASINE,ANABASINE,ANABASINE, DL-,(+/-)-ANABASINE
1-(2-Pyridinyl)-4-piperidinamine
1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID
N-[1-(3-CHLOROPYRIDIN-2-YL)PIPERIDIN-4-YL]ACETAMIDE
N-(beta-Hydroxypropyl)anabasine
(+)-Anabasine.HCl
N-Methylanabasine
2-(3,4,5,6-Tetrahydro-2H-[2,3']bipyridinyl-1-yl)-ethanol
ANABASINE HYDROCHLORIDE (3-(2-PIPERIDYL)PYRIDINE HYDROCHLORIDE),ANABASINE HYDROCHLORIDE
anabasamine