m7Gpp

m7Gpp C화학적 특성, 용도, 생산

용도

m7Gpp is an important intermediate for the synthesis of mRNA cap analogs.

Clinical claims and research

mRNA Cap analogs has the highest cost in all raw materails of mRNA vaccine. Like modified GAG, mofied GGG, etc. the synthetic steps are more than 18 operations. The total prorcess field is less than 15%. How to cut the cost of mRNA Cap analogs is the significant job for the mRNA commerial production.

Current market and forecast

Recent developments in mRNA cap analogs highlight the importance of mRNA as a powerful tool for studying RNA metabolism and uncover the potential of targeted mRNAs for cancer treatment, gene therapy, antiviral therapy and improved targeting of nuclease-targeted drugs.
Chemically modified mRNA cap analogs consist of the unique cap structure m7G [5'] ppp [5'] N (where N = G, A, C or U) and are present in many eukaryotic and viral 5' end RNAs and several non-coding RNAs. the presence of sugar substitutions on the m7G portion of the cap analog has a significant impact on the orientation, translation efficiency, binding affinity and nature of nuclear stability.
The synthesis of various cap analogs with 7-methylguanosine (m7G) sugar substitution modifications is a rather complex organic synthesis, usually with more than 18 reaction steps, using reagents and raw materials not readily available, such as 3'-propynyl, 2', 3'-isopropylidene, 2', 3'-diacetyl and 2' -amino, triphosphate bridging, e.g. iminodiphosphate and methylenebis(phosphonate); triphosphate non-bridging, e.g., BH3, Se and S; and nucleobase substitutions, e.g., 6-thioguanosine and triazole.

m7Gpp 준비 용품 및 원자재

원자재

준비 용품

m7Gpp 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Zhejiang Hengkang Pharmaceutical Co., Ltd.	+86-576-83372028 +86-18868723926	bd1@hengkangpharm.cn	China	119	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7154	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9425	58
JinOu Biomedical (Nanjing) Co., Ltd.	13000000000	jinoupharma@163.com	China	11732	58
Jiangsu Synthgene Biotechnology Co.,Ltd.	18136497538	znf@syngenebio.com	China	901	58
Nugene Biopharm Science (Hangzhou) Co., Ltd.	13326014885	service@nugene.com.cn	China	52	58

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