게페프린
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게페프린 속성
- 녹는점
- 155-158°
- 알파
- D25 +31.8° (c = 2 in methanol)
- 끓는 점
- 281.0±15.0 °C(Predicted)
- 밀도
- 1.070±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 9.86±0.10(Predicted)
안전
게페프린 C화학적 특성, 용도, 생산
Originator
Pressionorm,Helopharm,W. Germany,1981Manufacturing Process
Hydrolysis of D-(+)-1-(3-rnethoxyphenyl)-2-aminopropane: 2.42 mols (40 g) of the compound are dissolved in 6N hydrochloric acid in a bomb tube consisting of stainless steel and having a capacity of 500 ml. Hydrogen chloride gas is passed into the ice-cooled solution until this is saturated, The solution is then heated to 130°C for 2 hours in an air bath. After cooling and driving off the hydrochloric acid at a slightly elevated temperature, the hydrochloride of the 3-hydroxyphenyl derivative is present in the form of a yellowish syrup.The free base can be liberated from the hydrochloride by extracting a butanol solution of the hydrochloride several times with sodium bicarbonate solution. After recrystallization from isopropanol/ligroin, the yield of D-(+)-1-(3- hydroxyphenyl)-2-aminopropane amounts to 33.0 g, corresponding to 90.1% of theory relative to the D-form. Melting point = 152°C to 154°C.
Therapeutic Function
Antihypotensive게페프린 준비 용품 및 원자재
원자재
준비 용품
게페프린 공급 업체
글로벌( 17)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ShenZhen H&D Pharmaceutical Technology Co., LTD | +86-0755-22677845 +86-13627253706 |
sale@hdimpurity.com | China | 3095 | 58 |
JW & Y Pharmlab Co., Ltd. | 021-64340559 13651849907; |
xinyu_shi@jwypharmlab.com.cn | China | 12041 | 58 |
Bejing Famous Pharmaceutical Technology Co., Ltd. | 13331045123 |
1963319514@qq.com | China | 14232 | 58 |
Shanghai zhigan biotechnology co., LTD | |
zhiqianbio@126.com | China | 19785 | 58 |
Henan Pumei Jihua Pharmaceutical Technology Co., Ltd. | 037188900765 18037465274 |
enyawanglei@sina.cn | China | 13625 | 58 |
Shandong Wadesen Biotechnology Co. LTD | 0531-88723173 18596073690 |
1047208234@qq.com | China | 3857 | 58 |
Hubei Xinyang Medical Technology Co., Ltd | 15347293736 15347293736 |
2853117764@qq.com | China | 8527 | 58 |
Cato Research Chemicals Inc. | 020-81960175-877 18933936954 |
tianwen.zhan@cato-chem.com | China | 7721 | 58 |
Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 |
malulu@leyan.com | China | 40041 | 58 |
Shenzhen Qingtian Biotechnology Co, Ltd. | 18823167005 18162969855 |
744288988@qq.com | China | 2628 | 58 |