ACPA
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ACPA 속성
- 끓는 점
- 502.4±50.0 °C(Predicted)
- 밀도
- 0.93±0.1 g/cm3(Predicted)
- RTECS 번호
- JX3841600
- 저장 조건
- −20°C
- 용해도
- DMSO: 용해될 수 있다
- 산도 계수 (pKa)
- 16.13±0.20(Predicted)
- 물리적 상태
- 연한 노란색 오일.
- 색상
- Colorless to light yellow
- 감도
- Air Sensitive
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 3 |
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ACPA C화학적 특성, 용도, 생산
개요
Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 2.2 and 715 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.용도
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2 (CB2R).생물학적 활성
Potent and selective CB 1 agonist (K i = 2.2 nM). Displays 325-fold selectivity over CB 2 receptors. Active in vivo . Also available in water soluble emulsion (N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).효소 저해제
This highly selective, synthetic CB1 receptor agonist (FW = 343.55 g/mol; CAS 229021-64-1), also known as arachidonylcyclopropylamide and N(cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, targets CB1 cannabinoid receptor agonist (Ki = 2.2 nM) with >325-fold selectivity over CB2 receptors. Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. ACPA possesses the characteristics of CB1 receptor agonists, inhibiting forskolininduced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [35S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. See also ACEAACPA 준비 용품 및 원자재
원자재
준비 용품
ACPA 공급 업체
글로벌( 59)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
Ascent Scientific | 4401179829988 |
customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
Chemsky (shanghai) International Co.,Ltd | 021-50135380 |
shchemsky@sina.com | China | 15421 | 60 |
EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9707 | 58 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 |
sales@rechemscience.com | China | 2972 | 58 |
Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 |
amber@biochempartner.com | China | 3063 | 58 |
ACPA 관련 검색:
AM 251
ACEA
AM 630
2-AG
BML-190
5-(1,1-DIMETHYLHEPTYL)-2-[5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL
R(+)-ARACHIDONYL-1'-HYDROXY-2'-PROPYLAMIDE
ARACHIDONIC ACID-(2-AMINOETHYL)-ESTER HYDROCHLORIDE
ARACHIDONAMIDE
NOLADIN ETHER
MEAD ACID ETHANOLAMIDE
Arachidonyl-2′-chloroethylamide hydrate
BOC-ACPA-OH
FMOC-ACPA-OH
ACPA
BOC-ACPA-OH (1-(BOC-AMINOMETHYL)CYCLOPROPYL-1-CARBOXYLIC ACID)
AcpA protein