V-9-M콜레시스토키닌노나펩티드
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V-9-M콜레시스토키닌노나펩티드 속성
- 끓는 점
- 1350.7±65.0 °C(Predicted)
- 밀도
- 1.306±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 3.51±0.10(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- InChIKey
- AIKMAJWJXJPJNB-HNRKYVDVNA-N
안전
V-9-M콜레시스토키닌노나펩티드 C화학적 특성, 용도, 생산
개요
V-9-M Cholecystokinin nonapeptide is a glucagon-like peptide receptor agonist, namely GLP-1 receptor agonist. Human GLP-1 is a peptide hormone secreted by intestinal L cells. Cholecystokinin Precursor (24-32), rat has apparent sedative actions and prevents experimental amnesisa in rats.용도
V-9-M cholecystokinin nonapeptide belongs to the glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) class of hypoglycemic drugs, which increase insulin secretion in a glucose-dependent manner and inhibit glucagon secretion , and can promote gastric emptying, centrally suppress appetite, reduce food intake, and then reduce glucose absorption to achieve the effect of lowering blood sugar.일반 설명
V-9-M cholecystokinin nonapeptide, also known as Cholecystokinin Precursor (24-32) (rat), is a precursor compound of cholecystokinin (CCK) that is expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin (CCK) is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion, as well as a neurotransmitter. It can be extracted from the small intestine of dogs and cats and causes gallbladder contractions.Mechanism of action
V-9-M cholecystokinin nonapeptide's mechanism of action is to act on islet beta cells, promote the synthesis and secretion of insulin, stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of islet beta cells, increase the number of islet beta cells, and protect islet function. It can also act on islet alpha cells, inhibit the release of glucagon, and reduce the release of hepatic glucose.저장
Store at low temperatures to avoid moisture:Powder: -20°C, 3 years.
Solvents: -80°C, 2 years.
참고 문헌
1. Takashima A, Itoh S. Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat. Can J Physiol Pharmacol. 1989 Mar;67(3):223-7. DOI: 10.1016/0301-0082(90)90035-F2. Cholecytokinin (CCK) gene-related peptides: distribution and characterization of immunoreactive pro-CCK and an amino-terminal pro-CCK fragment in rat brain. DOI: 10.1016/0006-8993(85)90813-3
3. Cao G, Beinfeld MC. Calcium-dependent pro-cholecystokinin V-9-M immunoreactive peptide release from rat brain slices and CCK-secreting rat medullary thyroid carcinoma cells in culture. Peptides. 1992 Nov-Dec;13(6):1087-90. DOI: 10.1016/0196-9781(92)90011-Q
V-9-M콜레시스토키닌노나펩티드 준비 용품 및 원자재
원자재
준비 용품
V-9-M콜레시스토키닌노나펩티드 공급 업체
글로벌( 102)공급 업체
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qt01@qiangtaipharm.com | China | 84 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
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Hantai Biomedical Group Co. LTD | +8618819265912 |
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Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12449 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
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Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2972 | 58 |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 |
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CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 |
sales@anbuchem.com | China | 3000 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 |
sales@chembj.net | China | 289 | 58 |