D-에리스로-스핑고신-1-인산염
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D-에리스로-스핑고신-1-인산염 속성
- 녹는점
- 179-189°C
- 끓는 점
- 548.8±60.0 °C(Predicted)
- 밀도
- 1.094±0.06 g/cm3(Predicted)
- RTECS 번호
- RG2260500
- 저장 조건
- -20°C
- 용해도
- 메탄올: THF: 물(6:3:1): >0.5mg/mL
- 물리적 상태
- 밀랍 같은 고체
- 산도 계수 (pKa)
- 1.76±0.10(Predicted)
- 색상
- 노란색
- 감도
- Light Sensitive
- 안정성
- 습기, 온도에 민감함; 흡습성
- CAS 데이터베이스
- 26993-30-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
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위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
HS 번호 | 29225090 | ||
DEA Controlled Substances | CSCN: 1635 CAS SCH: IV NARC: N |
D-에리스로-스핑고신-1-인산염 C화학적 특성, 용도, 생산
개요
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively). Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity. S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.화학적 성질
Off-White to Grey Powder정의
ChEBI: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1일반 설명
Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants. Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine and regulates S1P levels. It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.생물학적 활성
Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors, S1P 1-5 . Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.D-에리스로-스핑고신-1-인산염 준비 용품 및 원자재
원자재
준비 용품
D-에리스로-스핑고신-1-인산염 공급 업체
글로벌( 122)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 |
ada@ipurechemical.com | CHINA | 3465 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
Nanjing Duly Biotech Co.,Ltd | +undefined18013301590 |
melody@njduly.com | China | 2452 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
D-에리스로-스핑고신-1-인산염 관련 검색:
(-)PPP
BORRELIDIN
Roscovitine
NVP-BEZ 235
Dihydrosphingosine(sphinganine)
SPHINGOMYELIN
D-ERYTHRO-SPHINGOSINE
CAGED D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE-13C2,D2
D-erythro-dihydro-D-sphingosine-1-phosphate
D-ERYTHRO-SPHINGOSINE 1-PHOSPHATE (CAGED)
N-ACETYL-D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE, [ACETYL-1-14C]
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE, N-OCTANOYL-