A
novel psychoactive drug chemically related to the hallucinogenic
agent MDA, but reported to be non-hallucinogenic.
Obtained by direct synthesis, at high doses it is reported to
show a stimulant-like effect in animals. Its LD50 is 97 mg/kg, i.
p., 49 mg/kg, i.p., 14 mg/kg, i.v., and 22 mg/kg, i.v. in mice,
rats, dogs, and monkeys, respectively. At higher doses, MDMA
has pressor effects and produces tachycardia, and causes damage
to serotonin neurons in both rats and monkeys. The (S)-
(1)-enantiomer is more active than the (R)-(?′)-enantiomer and,
like amphetamine, the pharmacological effects may be due to a
release of endogenous monoamine neurotransmitter, probably
serotonin and/or norepinephrine. MDMA is also an inhibitor of
monoamine uptake into brain synaptosomes. Symptoms
include pronounced mydriasis, with nystagmus and jaw clenching,
and nausea also is often reported. This substance produces a feeling of well-being and euphoria and is similar in some
respects to MDA, in that it seems to enhance a sense of empathy
and emotional openness in users. Toxic reactions would
appear to occur as a result of the pressor action, and sympathomimetic
effects of the drug. No appropriate therapeutic intervention
has been reported. Peripheral adrenergic blocking
agents, or chlorpromazine, have been used, however, to prevent
death in dogs following a lethal i.v. dose of the chemically
related agent MDA.
장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재)
특정 표적장기 독성 - 1회 노출
구분 1
위험
P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P210
열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260
분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P311
의료기관(의사)의 진찰을 받으시오.
(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE C화학적 특성, 용도, 생산
정의
ChEBI: A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a 2-(methylamino)propyl group at position 5.
신진 대사 경로
Four biotransformation pathways of 3,4-
(methylenedioxy)methamphetamine (MDMA) in rats
are identified as N-demethylation, O-dealkylation,
deamination, and conjugation (O-methylation, O-
glucuronidation, and/or sulfation). Specific MDMA
metabolites identified are 3-hydroxy-4-
methoxymethamphetamine, 4-hydroxy-3-
methoxymethamphetamine, 3,4-
dihydroxymethamphetamine, 4-hydroxy-3-
methoxyamphetamine, 3,4-
(methylenedioxy)amphetamine (MDA), (4-hydroxy-3-
methoxyphenyl)acetone, [3,4-
(methylenedioxy)phenyl]acetone, and (3,4-
dihydroxyphenyl)acetone. MDMA is metabolized by 10 000 g rat liver supernatant to 4-hydroxy-3-
methoxymethamphetamine, 3,4-
dihydroxymethamphetamine, MDA, and [3,4-
(methylenedioxy)phenyl]acetone. Also, the 10 000 g
rat brain supernatant metabolizes MDMA to 4-hydroxy-
3-methoxymethamphetamine, 3,4-
dihydroxymethamphetamine, 4-hydroxy-3-
methoxyamphetamine, and MDA.
(+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE 준비 용품 및 원자재
