1,2-DIPALMITOYL-SN-글리세롤
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1,2-DIPALMITOYL-SN-글리세롤 속성
- 녹는점
- 66-69 °C
- 끓는 점
- 620.8±22.0 °C(Predicted)
- 밀도
- 0.930±0.06 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- DMF: 20 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .25 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 13.69±0.10(Predicted)
- 색상
- White to off-white
- BRN
- 1730209
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
WGK 독일 | 1 | ||
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F 고인화성물질 | 10 |
그림문자(GHS): |
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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1,2-DIPALMITOYL-SN-글리세롤 C화학적 특성, 용도, 생산
용도
1,2-Dipalmitoyl-sn-glycerol (1,2-DPG) is an analog of the protein kinase C (PKC)-activating second messenger diacylglycerol. 1,2-Dipalmitoyl-sn-glycerol is a weak activator of PKC.정의
ChEBI: A 1,2-diacyl-sn-glycerol in which both acyl groups are specified as palmitoyl (hexadecanoyl).일반 설명
In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.
Purification Methods
Crystallise S(-)-1,2-dipalmitin from chloroform/pet ether (b 40-60o) ~1:1.5. [S(-)-isomer: Baer & Kates J Am Chem Soc 72 942 1950, Hanahan & Vercamer J Am Chem Soc 7 6 1804 1954, R(+)-isomer: Tattrie et al. Arch Biochem 78 319 1958, Beilstein 2 IV 1173.] The racemate [40290-32-2] is polymorphic with different IR spectra. When crystallised from hexane, or other solvents, the higher melting form with m 71.5-72.5o is obtained. The melt then solidifies to give the lower melting -form with m 49.7-50o. The -form has m 61o (65-66o is also reported). When the lower melting forms are kept at their melting temperatures for a while, they are converted to the higher melting form. [Howe & Malkin J Chem Soc 2663 1951, Baer & Kates J Am Chem Soc 72 942 1950, Beilstein 2 IV 1173.]1,2-DIPALMITOYL-SN-글리세롤 준비 용품 및 원자재
원자재
준비 용품
1,2-DIPALMITOYL-SN-글리세롤 공급 업체
글로벌( 89)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 |
1057@dideu.com | China | 3957 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19915 | 58 |
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
PT CHEM GROUP LIMITED | |
peter68@ptchemgroup.com | China | 35426 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 |
sales@sinch.com.cn | China | 11605 | 64 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 94658 | 76 |
1,2-DIPALMITOYL-SN-글리세롤 관련 검색:
파미틴 산 1,2,3-프로페인트라이일 옥타데칸산염 1,2,3-프로판트라이일 헥사데칸산
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
1,2-DIHEPTADECANOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
1,2,3-TRINONADECANOYLGLYCEROL
TRIHEPTADECANOIN
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
TRIARACHIDIN
1,2-Distearoyl-sn-glycero-3-phosphocholine
TRIBEHENIN
1,3-DIPALMITIN
1-O,2-O-Dipalmitoyl-sn-glycerol,1,2-DIPALMITOYL-SN-GLYCEROL
DIPALMITIN
1,2-DIHEXADECANOYL-SN-GLYCERO-3-PHOSPHO[DIMETHYLAMINOETHANOL]
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE CALCIUM SALT
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE