CALMIDAZOLIUM CHLORIDE

CALMIDAZOLIUM CHLORIDE 구조식 이미지
카스 번호:
57265-65-3
상품명:
CALMIDAZOLIUM CHLORIDE
동의어(영문):
R 24571;CALMIDAZOLIUM;COMPOUND 48/80;Calimidazoline;COMPOUND R24571;R 24571 CHLORIDE;Calmidazolium chlori;CALMIDAZOLIUM CHLORIDE;Calmidazolium chloride,99%;CALMODULIN INHIBITOR R 24571
CBNumber:
CB4231628
분자식:
C31H23Cl7N2O
포뮬러 무게:
687.69
MOL 파일:
57265-65-3.mol
MSDS 파일:
SDS

CALMIDAZOLIUM CHLORIDE 속성

녹는점
172-176 °C
저장 조건
2-8°C
용해도
Soluble to 100 mM in DMSO and to 100 mM in ethanol
물리적 상태
고체
물리적 상태
단단한 모양
색상
하얀색
수용성
디메틸 설폭사이드, 에탄올, 메탄올, 클로로포름 및 프로필렌 글리콜에 용해됩니다. 물에는 녹지 않음.
BRN
6470244
안전
  • 위험 및 안전 성명
안전지침서 22-24/25
유엔번호(UN No.) UN 2811 6.1 / PGII
WGK 독일 3
RTECS 번호 Gk2402500
F 고인화성물질 3-8-10
HS 번호 29332990
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
NFPA 704
0
2 0

CALMIDAZOLIUM CHLORIDE C화학적 특성, 용도, 생산

화학적 성질

white to off-white powder

용도

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

일반 설명

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

생물학적 활성

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

CALMIDAZOLIUM CHLORIDE 준비 용품 및 원자재

원자재

준비 용품


CALMIDAZOLIUM CHLORIDE 공급 업체

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