올라넥시딘
|
|
올라넥시딘 속성
- 끓는 점
- 454.7±55.0 °C(Predicted)
- 밀도
- 1.22±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 11.92±0.10(Predicted)
안전
올라넥시딘 C화학적 특성, 용도, 생산
개요
In July 2015, olanexidine gluconate, a biguanide compound with remarkable antibacterial activity, was approved by the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan for skin antisepsis at surgical sites. The drug was developed and marketed by Otsuka Pharmaceutical in Japan and is available as topical solution (1.5%). Olanexidine gluconate exhibited efficacy against a wide range of bacterial strains, especially Grampositive bacteria. In vitro experiments exploring its mechanism of action indicated that olanexidine interacts with bacterial surface molecules (such as lipopolysaccharides and lipoteichoic acid), disrupting the cell membranes of liposomes. These models suggest that the drug permeates the membranes of both Escherichia coli and Staphylococcus aureus and denatures proteins at relatively high concentrations (>160 g/mL).Synthesis
The synthesis of olanexidine gluconate is relatively straightforward, involving the linkage of an n-octyl side chain and a dichlorobenzylamine through a bis-guanidyl lynchpin. The synthesis began with the reaction of commercial noctylamine (17) with sodium dicyanamide in the presence of concentrated sulfuric acid in refluxing n-butyl acetate to give rise to 1-cyano-3-octylguanidine (18) in 86% yield . Conditions employed to subsequently secure biguanidine 20 as the HCl salt hemihydrate in 77% yield were nearly identical to those used for the conversion of 17 to 18. Finally, treatment of 20 with sodium hydroxide in the presence of gluconic acid (21) gave rise to olanexidin gluconate (II) in almost quantitative yield.올라넥시딘 준비 용품 및 원자재
원자재
준비 용품
올라넥시딘 공급 업체
글로벌( 22)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Adamas Reagent, Ltd. | 400-6009262 16621234537 |
chenyj@titansci.com | China | 14104 | 59 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 |
klq@cw-bio.com | China | 4184 | 55 |
Zhengzhou Acme Chemical Co., Ltd. | 0371-037163312495,13303845143 13303845143 |
3001379618@qq.com | China | 10018 | 58 |
Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd. | 0531-58897130 15508676053 |
drug_impurity@sdcclh.com | China | 1932 | 58 |
Jinan blalong chemical co. LTD | 2710913286@.com |
1513643261@qq.com | China | 14253 | 58 |
올라넥시딘 관련 검색:
3,4-DICHLOROBENZYLAMINE HYDROCHLORIDE
OLANEXIDINE intermediate
Olanexidine Impurity 3
(3,4-Dichlorobenzyl)methylamine
Olanexidine Impurity
2,3-Dichlorobenzylamine
3,4-Dichlorobenzylamine
Oxiracetam
Olanexidine Impurity
2,4-Dichlorobenzylamine
(3,4-DICHLOROBENZYL)-GUANIDINE
Poly(hexamethylenebiguanide)
OLANEXIDINE