눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
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NS 1738 C화학적 특성, 용도, 생산
개요
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
용도
NS 1738 is a selective a7 nAchR allosteric modulator.
생물학적 활성
Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .
