눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P342+P311
호흡기 증상이 나타나면 의료기관(의사)의 진찰을 받으시오.
NFPA 704
0
3
0
1,1-디메틸에틸-N-[(4-클로로페닐)메틸]-N-[(5-니트로-2-티에닐)메틸])글리시네이트 C화학적 특성, 용도, 생산
용도
GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
Biochem/physiol Actions
GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.
1,1-디메틸에틸-N-[(4-클로로페닐)메틸]-N-[(5-니트로-2-티에닐)메틸])글리시네이트 준비 용품 및 원자재
원자재
준비 용품
1,1-디메틸에틸-N-[(4-클로로페닐)메틸]-N-[(5-니트로-2-티에닐)메틸])글리시네이트 공급 업체
![1,1-디메틸에틸-N-[(4-클로로페닐)메틸]-N-[(5-니트로-2-티에닐)메틸])글리시네이트](CAS/GIF/1216744-19-2.gif)
