GN25

GN25 구조식 이미지
카스 번호:
1227401-27-5
상품명:
GN25
동의어(영문):
GN25;DIIRLGMLDOPLPV-UHFFFAOYSA-N;Propanoic acid, 3-[(1,4-dihydro-5,8-dimethoxy-1,4-dioxo-2-naphthalenyl)thio]-
CBNumber:
CB42591113
분자식:
C15H14O6S
포뮬러 무게:
322.33
MOL 파일:
1227401-27-5.mol

GN25 속성

끓는 점
608.4±55.0 °C(Predicted)
밀도
1.42±0.1 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
물리적 상태
결정질 고체
산도 계수 (pKa)
4.24±0.10(Predicted)

안전

GN25 C화학적 특성, 용도, 생산

개요

The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.

GN25 준비 용품 및 원자재

원자재

준비 용품


GN25 공급 업체

글로벌( 34)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131980 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8141 58
Shanghai Universal Biotech Co.,Ltd 13774214275
gaojun@univ-bio.com China 24990 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337
3427709316@qq.com China 7979 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 11975 58
RD International Technology Co., Limited 18024082417
market@ubiochem.com China 9268 58
ApexBio Technology --
sales@apexbt.com United States 6254 58

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