(2R,3S,11bR)-Dihydrotetrabenazine is an enantiomer of?(2S,3R,11bS)-Dihydrotetrabenazine (D454920). Tetrabenazine?and dihydrotetrabenazines are potent inhibitors of?vesicular monoamine transporter 2?(VMAT2). Furthermore, the derivatives of these compounds are potential drug candidates for treating various diseases such as?Huntington’s disease and other hyperkinetic disorders.