Anti-Hlcd;Anti-IFIH1;Anti-IDDM19;Anti-MGC133047;Anti-MDA-5 antibody produced in rabbit;Anti-IFIH1 antibody produced in rabbit;Anti-MDA5/IFIH1 antibody produced in goat;Anti-Helicard antibody produced in rabbit;Anti-Melanoma differentiation-associated protein 5;Anti-Interferon-induced with helicase C domain protein 1
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
Anti-MGC133047 C화학적 특성, 용도, 생산
용도
Anti-MDA5 antibody produced in rabbit has been used in western blot analysis.
일반 설명
Melanoma differentiation-associated protein 5 (MDA5), also known as interferon induced with helicase C domain 1 (IFIH1), is a cytosolic RNA sensor. It is encoded by the gene mapped to human chromosome 2q24.2. The encoded protein is a member of the retinoic acid-inducible gene I-like receptor family. MDA5 is characterized with both caspase recruitment domain and putative DExH group RNA helicase domains.
Biochem/physiol Actions
Melanoma differentiation-associated protein 5 (MDA5) plays a vital role in antiviral innate immune responses. In addition, the encoded protein also activates interferon regulatory factors 3 and 7 and nuclear factor-κB (NF-κB) via a mitochondrial viral signaling protein, inducing antiviral and proapoptotic responses, which is associated with various autoimmune diseases, such as type 1 diabetes (T1D), Graves′ disease (GD), multiple sclerosis (MS), psoriasis and rheumatoid arthritis (RA). Polymorphism in the gene is associated with the development of generalized vitiligo (GV).
