트리미프라민
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트리미프라민 속성
- 녹는점
- 45°
- 끓는 점
- 426.2°C (rough estimate)
- 밀도
- 0.9912 (rough estimate)
- 굴절률
- 1.6450 (estimate)
- 인화점
- 9℃
- 저장 조건
- 2-8°C
- 산도 계수 (pKa)
- pKa 8.0 (Uncertain)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | F,T | ||
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위험 카페고리 넘버 | 11-23/24/25-39/23/24/25 | ||
안전지침서 | 16-36/37-45 | ||
유엔번호(UN No.) | 3249 | ||
WGK 독일 | 1 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
독성 | LD50 oral in mouse: 250mg/kg |
그림문자(GHS): |
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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트리미프라민 C화학적 특성, 용도, 생산
용도
Antidepressant.정의
ChEBI: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)-2-methylpropyl group at the nitrogen atom. It is used as an antidepressant.World Health Organization (WHO)
Trimipramine, a tricyclic antidepressant was introduced in 1961 for the management of endogenous depression. Much of the adverse effects are caused by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders and risk of suicide. The risk of suicide and dangers related to overdosage led Norwegian Medicines Control Authority to put the higher strength formulation under prescribing restriction in 1992. The risk of death following overdosage is apparently higher for products containing tricyclic compounds as compared with nontricyclic products.Pharmacokinetics
Trimipramine is one of the antidepressants with the most pronounced differences in pharmacokinetics caused by the CYP2D6 genetic polymorphism. Its bioavailability and systemic clearance depended significantly on the CYP2D6 isoform with a linear dose relationship. Its mean bioavailability was 44% in individuals without CYP2D6 (poor metabolizers) but 16 and 12% in those individuals with two and three active genes of CYP2D6 (fast and ultrafast metabolizers), respectively. Consequently, the mean total clearances of the oral dose were 27, 151, and 253 L/hour in poor, extensive, and ultrarapid metabolizers, respectively. The 44% bioavailability combined with low systemic clearance of trimipramine in poor metabolizers of CYP2D6 substrates results in a very high exposure to trimipramine with the risk of adverse drug reactions. On the other hand, the presystemic elimination may result in subtherapeutic drug concentrations in carriers of CYP2D6 gene duplications with a high risk of poor therapeutic responseClinical Use
Although trimipramine has the weakest binding affinity for the monoamine transporters, it shares the pharmacological and toxicity actions of the other TCAs and is used primarily in the treatment of depression.트리미프라민 준비 용품 및 원자재
원자재
준비 용품
트리미프라민 공급 업체
글로벌( 43)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30253 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 9003 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 19947 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2127 | 70 |
Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 |
info@yuhaochemical.com | China | 9394 | 52 |
Shanghai Sphchem Co., Ltd. | 21-21-56491756 13512199871 |
sales@panhongchem.com | China | 3997 | 55 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
AdooQ Bioscience CHINA | 025-58849295 18951903616; |
info@adooq.cn | China | 2989 | 60 |
트리미프라민 관련 검색:
트라조돈
trimipramine hydrogen maleate,TRIMIPRAMINE MALEATE METHANOL SOLUTION,Trimipramine solution maleate salt,TRIMIPRAMINE MALEATE,TRIMIPRAMINE MALEATE SALT
Trimipramine-D3 maleate
ISOCARBOXAZID (200 MG)
Citalopram
Triprolidine oxalate salt
IMIPRAMINE
Miboplatin
TRIMIPRAMINE
Trimipramine-d3 Maleate Salt
TRIMIPRAMINE MESYLATE/TRIMIPRAMINE MESILATE,TRIMIPRAMINE MESILATE
2-Hydroxy Trimipramine-d3
2-Hydroxy Trimipramine
TRIMIPRAMINE-D3 MALEATE (N-METHYL-D3)
Trimipramine for peak identification
(S)-Trimipramine
(R)-Trimipramine
TRIMIPRAMINE HYDROCHLORIDE, [N-METHYL-3H]