메나디온
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메나디온 속성
- 녹는점
- 105-107 °C(lit.)
- 끓는 점
- 262.49°C (rough estimate)
- 밀도
- 1.1153 (rough estimate)
- 굴절률
- 1.5500 (estimate)
- 저장 조건
- room temp
- 용해도
- 기름: 용해성
- 물리적 상태
- 수정 같은
- 색상
- 노란색
- 냄새
- 약간의 냄새
- 수용성
- 불용성
- 감도
- Light Sensitive
- Merck
- 14,5831
- BRN
- 1908453
- 안정성
- 안정적인. 빛에 민감할 수 있습니다. 강한 산화제와 호환되지 않습니다.
- InChIKey
- MJVAVZPDRWSRRC-UHFFFAOYSA-N
- LogP
- 2.200
- CAS 데이터베이스
- 58-27-5(CAS DataBase Reference)
- NIST
- Menadione(58-27-5)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-43 | ||
안전지침서 | 26-36-37/39-24 | ||
WGK 독일 | 3 | ||
RTECS 번호 | QL9100000 | ||
F 고인화성물질 | 8 | ||
TSCA | Yes | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29147000 | ||
유해 물질 데이터 | 58-27-5(Hazardous Substances Data) | ||
독성 | LD50 orally in mice: ~0.5 g/kg (Molitor, Robinson) | ||
유해화학물질 필터링 | 2018-1-835(신규화학물질) | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 2-메틸-1,4-나프탈렌디온 및 이를 25% 이상 함유한 혼합물 |
메나디온 C화학적 특성, 용도, 생산
개요
Vitamin K is a general term referring to a group of naphthoquinone derivatives required in the diet for blood clotting. Menadione is a fat-soluble vitamin that is essential for blood clotting. It is destroyed by irradiation during processing but has no appreciable loss during storage. It occurs in spinach, cabbage, liver, and wheat bran.화학적 성질
Bright-yellow crystals with a very faint acrid odour. Insoluble in water; soluble in benzene (1 g/10 mL), ethanol (1 g/60 mL), and vegetable oils (1g/50 mL); moderately soluble in carbon tetrachloride and chloroform. Stable in air; decomposed by sunlight; destroyed by alkalis and reducing agents.물리적 성질
Appearance: phylloquinone is a yellow oil at room temperature, but the other vitamers K are yellow crystals. Solubility: the vitamers K and MK and most forms of menadione are insoluble in water, slightly soluble in ethanol, and readily soluble in ether, chloroform, fats, and oils. Stability: the vitamers K are sensitive to light and alkali, but are relatively stable to heat and oxidizing environments.Menadione, the formal parent compound of the menaquinone series does not occur naturally but is a common synthetic form called menadione (2-methyl-1,4- naphthoquinone). This compound forms a water-soluble sodium bisulfite addition product, menadione sodium bisulfite, whose practical utility is limited by its instability in complex matrices such as feeds. However, in the presence of excess sodium bisulfite, it crystallizes as a complex with an additional mole of sodium bisulfite (i.e., menadione sodium bisulfite complex), which has greater stability, therefore, is used widely as a supplement to poultry feeds. A third water-soluble compound is menadione pyridinol bisulfite (MPB).
용도
Menadione is precursor to verious types of Vitamin K. It is of industrial importance as an intermediate in the synthesis of phylloquinone, and salts of its bisulfite adduct are used as stabilized forms in the animal feed industry. Commercially significant forms are menadione sodium bisulfite and menadione dimethyl pyrimidinol. Used as a micronutrient for livestock and pet foods.주요 응용
The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. It is being incorporated into cosmetic preparations, particularly those used for treating dark circles. It could also be used in acne products, and there are studies underway on its efficacy for the treatment of spider veins.제조 방법
Menadione can be prepared by oxidizing 2-methylnaphthalene with chromic acid or hydrogen peroxide.정의
ChEBI: Menadione is a member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia. It has a role as a nutraceutical, a human urinary metabolite, an angiogenesis inhibitor, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor and an antineoplastic agent. It is a member of 1,4-naphthoquinones and a vitamin K.Indications
Vitamin K activity is associated with several quinones, including phylloquinone (vitamin K1), menadione (vitamin K3), and a variety of menaquinones (vitamin K2). These quinones promote the synthesis of proteins that are involved in the coagulation of blood.These proteins include prothrombin, factor VII (proconvertin), factor IX (plasma thromboplastin). The vitamin K quinones are obtained from three major sources.Vitamin K is present in various plants, especially green vegetables. The menaquinones that possess vitamin K2 activity are synthesized by bacteria, particularly gram-positive organisms; the bacteria in the gut of animals produce useful quantities of this vitamin.Vitamin K3 is a chemically synthesized quinone that possesses the same activity as vitamin K1.일반 설명
Menadione is a prothrombogenic compound and belongs to the Vitamin K class of compounds, which are necessary for the biosynthesis of prothrombin and other blood clotting factors. It is used as a model quinone in cell culture and in vivo investigations. It is obtained as a catabolic product of phylloquinone and circulating precursor of tissue menaquinone-4 in rats.위험도
Irritant to skin and mucous membranes, especially the alcoholic solution.Pharmacology
The typical role of vitamin K is to maintain normal blood coagulation function. Its role is related to the metabolic processes.Clinical Use
Vitamin K deficiency results in increased bleeding time. This hypoprothrombinemia may lead to hemorrhage from the gastrointestinal tract, urinary tract, and nasal mucosa. In normal, healthy adults, deficiency is rare. The two groups at greatest risk are newborn infants and patients receiving anticoagulant therapy; hypoprothrombinemia preexists in these two groups. Any disease that causes the malabsorption of fats may lead to deficiency. Inhibition of the growth of intestinal bacteria from extended antibiotic therapy will result in decreased vitamin K synthesis and possible deficiency.부작용
Toxicity of vitamin K has not been well defined. Jaundice may occur in a newborn if large dosages of vitamin K are given to the mother before birth. Although kernicterus may result, this can be prevented by using vitamin K.Safety Profile
Poison by ingestion, intraperitoneal, and subcutaneous routes. Experimental teratogenic effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.Purification Methods
Recrystallise it from 95% EtOH, or MeOH after filtration. It forms bright yellow crystals which are decomposed by light. Its solubility in EtOH is 1.7% and in *C6H6 it is 10%. It IRRITATES mucous membranes and skin. [Fieser J Biol Chem 133 391 1940, Beilstein 7 IV 2430.]메나디온 준비 용품 및 원자재
원자재
메틸나프탈렌
중크롬산나트륨
1,3-부타디엔
메틸나프탈렌
크롬(6+) 트리산화물
중크롬산 칼륨
2-메틸나프탈렌
황산
3,3'-DIMETHYLNAPHTHIDINE
과산화 수소
아세트산(빙초산)
준비 용품
메나디온 공급 업체
글로벌( 601)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Suzhou Laing Biotechnology Co.,Ltd | +86-13004516015 +86-18149392822 |
christina@laingbiotec.com | China | 778 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34571 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019 +86-15383190639 |
admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |