소부족산
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소부족산 속성
- 녹는점
- 128-130°; mp 132-133° (Cai, 1989)
- 끓는 점
- 664.9±55.0 °C(Predicted)
- 밀도
- 1.272±0.06 g/cm3(Predicted)
- 용해도
- DMSO: 19mg/mL
- 산도 계수 (pKa)
- 2.75±0.20(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
안전
| WGK 독일 | 2 | ||
|---|---|---|---|
| RTECS 번호 | FG1582500 | ||
| 독성 | LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa) |
소부족산 C화학적 특성, 용도, 생산
개요
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.용도
Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.소부족산 준비 용품 및 원자재
원자재
준비 용품
소부족산 공급 업체
글로벌( 13)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2127 | 70 |
| Heterochem | 027-88041443 13072715837 |
sales@hetero-chem.com | China | 696 | 58 |
| United States Biological | -- |
sales@advtechind.com | United States | 6106 | 58 |