Brodifacoum is a 4-hydroxycoumarin anticoagulant that acts as
a vitamin K antagonist. It was registered as a pesticide in 1979
in the United States although in 2008 it was made a restricted
use pesticide by the Environmental Protection Agency. This
means it can only be used by certified pesticide applicators;
however, the makers of D-Con which contains 0.005% brodifacoum
by weight have challenged this and brodifacoum is
currently available in D-Con and in various other pesticide
products for the eradication of mice and rats although it is also
used on larger mammals such as possums. Brodifacoum
currently remains available to the general public.
화학적 성질
White Solid
용도
Brodifacoum is a highly lethal vitamin K antagonist anticoagulant poison. In recent years, Broadifacoum, has become one of the world's most widely used pesticides.
위험도
Poison, anticoagulant.
환경귀착
Brodifacoum, like other hydroxycoumarins, interferes with the
production of vitamin K–dependent coagulation factors.
Vitamin K is a cofactor for the carboxylation of specific glutamic
acid groups in coagulation factors II (prothrombin), VII,
IX, and X. During this step, vitamin K is oxidized to vitamin K
2,3-epoxide. The regeneration of vitamin K by vitamin K
2,3-epoxide reductase is prevented by brodifacoum. As a result,
dysfunctional decarboxy-coagulation factors are produced and
coagulation is impaired. Brodifacoum is over 100 times more
potent than warfarin on a molar basis in rats.
신진 대사 경로
The fate of brodifacoum in soils and plants has not been studied in detail
because the compound is usually applied as a pelleted bait or in a wax
block. This limits its dissipation in the environment. Studies in animals
have been conducted as part of the assessment of safety and to investigate
mode of action.
