스탈리마이신
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스탈리마이신 속성
- 녹는점
- 154-156°
- 끓는 점
- 579.2°C (rough estimate)
- 밀도
- 1.3298 (rough estimate)
- 굴절률
- 1.6910 (estimate)
안전
스탈리마이신 C화학적 특성, 용도, 생산
Originator
Herperal,Farmitalia,Italy,1978Manufacturing Process
A spore suspension obtained upon washing a culture of Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following:Dextrose 2% Corn steep liquor extract 2% CaCO3 1% (NH4)2SO4 0.3% NaCl 0.3%Fermentation is continued at 28°C for 40 hours at a stirring rate of 150 to 250 rpm and a rate of air flow of 1 to 2 l/min/l of culture medium.300 ml of a suspension of the vegetative mycelium of this culture are used for inoculating 6,000 ml of a similar sterile culture medium. At this production stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 28°C) at a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 l/min/l of culture medium.
To 17 l of a culture obtained by submerged fermentation as mentioned above, siliceous earth is added and the batch is filtered. The mixture of mycelium and the siliceous earth are agitated for 1 hour with 2.5 l of butanol. This treatment is repeated twice. The butanolic extracts are combined, washed with water, evaporated to dryness (about 10 g) and boiled with acetone (80 ml). The 5 g of distamycin is extracted six times with ethanol. The ethanolic extracts are combined, concentrated and filtered through a column containing 70 g of alumina. Elution is carried out with the same solvent. The effluent (central fractions) is collected and evaporated to dryness to yield 0.43 g of pure distamycin A: decomposition point, 183°C to 185°C. The product can be further purified by crystallization from aqueous n-butanol.
Therapeutic Function
Antibiotic스탈리마이신 준비 용품 및 원자재
원자재
준비 용품
스탈리마이신 공급 업체
글로벌( 7)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 |
sales@chem-strong.com | China | 18018 | 56 |
Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 |
jiangnan@huidabiotech.com | China | 3657 | 58 |
Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 |
sunshixuan@huidabiotech.com | China | 3705 | 58 |
Hangzhou Hesheng Taiyi Biotechnology Co. , Ltd. | 15868607770 |
hstysales@126.com | China | 1163 | 58 |
Shanghai Yanchun Biopharmaceutical Technology Co., Ltd | 4001-009266 17349750668 |
product@sci-e.com | China | 2811 | 58 |
스탈리마이신 관련 검색:
1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((3-amino-3-iminopro pyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, dihydrochlorid e
1H-Pyrrole-2-carboxamide, 4-(((4-((((aminoiminomethyl)amino)acetyl)ami no)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((2-(aminoiminomethy l)-1-methylethyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl-, d ihydrochloride
Stallimycin
DISTAMYCIN A HYDROCHLORIDE
Tallimustine