α-hydro-ω-하이드록시 폴리(옥시-1,2-에탄디일) 12-하이드록시옥타데카노익산 폴리머 with
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α-hydro-ω-하이드록시 폴리(옥시-1,2-에탄디일) 12-하이드록시옥타데카노익산 폴리머 with 속성
- 인화점
- 272℃
- 저장 조건
- Refrigerator
- 용해도
- 물에 매우 잘 녹고, 에탄올(96%)에 잘 녹으며, 유동 파라핀에는 녹지 않습니다. 약 25°C에서 응고됩니다.
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 투명한 무색 오일에서 황백색으로
- 냄새
- 목련 흰 꽃 신선한 감귤류의 자연의
- 수소이온지수(pH)
- 5.0-7.0 (1g/10 mL in H2O)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
α-hydro-ω-하이드록시 폴리(옥시-1,2-에탄디일) 12-하이드록시옥타데카노익산 폴리머 with C화학적 특성, 용도, 생산
화학적 성질
Yellowish, waxy mass.용도
Non-ionic surfactant.생산 방법
Macrogol 15 hydroxystearate is produced by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxystearic acid.Pharmaceutical Applications
Macrogol 15 hydroxystearate is frequently used in preclinical testing of drugs, mainly for IV and other parenteral applications. The solubilizing capacity for some tested drugs (clotrimazole, carbamazepine, 17 β-estradiol, sulfathiazole, and piroxicam) increases almost linearly with increasing concentration of solubilizing agent. This is due to the formation of spherical micelles even at high concentrations of macrogol 15 hydroxystearate. Similarly, tests have revealed that viscosity increases with increasing amount of solubilizer, but the amount of solubilized drugs does not have any additional influence on the kinematic viscosity. Lipid nanocapsules comprising macrogol 15 hydroxystearate and soybean phosphatidylcholine containing 3% docetaxel have been successfully prepared by a solvent-free inversion process.Macrogol 15 hydroxystearate has been used in the manufacture of aqueous parenteral preparations with vitamin A, D, E and K, and a number of other lipophilic pharmaceutical active agents, such as propanidid, miconazole, alfadolone, and alfaxalone. It is very efficient at solubilizing substances like fat-soluble vitamins and active ingredients of hydrophobic nature. It is also an excellent solubilizer for parenteral use, at a concentration of 20%, and the water solubility of different drugs may be enhanced by a factor of 10–100, depending on the structure of the drug molecule.
Safety
Macrogol 15 hydroxystearate is used in parenteral pharmaceutical preparations in concentrations up to 50% to solubilize diclofenac, propanidid, and vitamin K1. It has also been used in preclinical formulations in preparing supersaturated injectable formulations of water-insoluble molecules. It is generally regarded as a relatively nontoxic and nonirritant excipient.Macrogol 15 hydroxystearate is reported not to be mutagenic in bacteria, mammalian cell cultures and mammals.
LD50 (dog, IV): >3.10 g/kg
LD50 (mouse, IP): >0.0085 g/kg
LD50 (mouse, IV): >3.16 g/kg
LD50 (rabbit, IV): 1.0–1.4 g/kg
LD50 (rat, oral): >20 g/kg
LD50 (rat, IV): 1.0–1.47 g/kg
저장
Macrogol 15 hydroxystearate has a high chemical stability. The prolonged action of heat may induce physical separation into a liquid and a solid phase after cooling, which can be reversed by subsequent homogenization. Macrogol 15 hydroxystearate is stable for at least 24 months if stored in unopened airtight containers at room temperature (maximum 25 °C). Aqueous solutions of macrogol 15 hydroxystearate can be heat-sterilized (121°C, 0.21 MPa). The pH may drop slightly during heating, which should be taken into account. Separation into phases may also occur, but agitating the hot solution can reverse this. Aqueous solutions can be stabilized with the standard preservatives used in pharmaceuticals.Macrogol 15 hydroxystearate should be stored in tightly sealed containers in a dry place.
Regulatory Status
Included in the Canadian List of Acceptable Non-medicinal Ingredients.α-hydro-ω-하이드록시 폴리(옥시-1,2-에탄디일) 12-하이드록시옥타데카노익산 폴리머 with 준비 용품 및 원자재
원자재
준비 용품
α-hydro-ω-하이드록시 폴리(옥시-1,2-에탄디일) 12-하이드록시옥타데카노익산 폴리머 with 공급 업체
글로벌( 52)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21671 | 55 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13056 | 58 |
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6393 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20314 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615350571055 |
Sibel@weibangbio.com | China | 4822 | 58 |
α-hydro-ω-하이드록시 폴리(옥시-1,2-에탄디일) 12-하이드록시옥타데카노익산 폴리머 with 관련 검색:
폴리에틸렌글리콜#300
Methoxypolyethylene glycols
Poly(ethylene glycol) diacrylate
Diethylene glycol diglycidyl ether
400DL
Polyethylene glycol 200 dilaurate
Polyethylene glycol 6000 monooleate
POLY(ETHYLENE GLYCOL) METHYL ETHER METHACRYLATE
Polyethylene glycol 4000 monooleate
Allyloxypolyethyleneglycol
Polyethylene glycol monolaurate
Polyethylene glycol dimethyl ether
Polyethylene glycol 400 monooleate
Polyethylene glycol 400 dioleate
600MO