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ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate 구조식 이미지

카스 번호:: 4450-98-0

상품명:: ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

동의어(영문):: 1-Ebpc;CP-10668;Nsc 229530;Aldose Reductase,inhibit,EBPC,Inhibitor;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester

CBNumber:: CB51373216

분자식:: C14H15NO4

포뮬러 무게:: 261.27

MOL 파일:: 4450-98-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 23

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate 속성

녹는점: 135-136 °C

끓는 점: 479.8±45.0 °C(Predicted)

밀도: 1.340±0.06 g/cm3(Predicted)

저장 조건: room temp

용해도: DMSO: ≥10mg/mL

물리적 상태: 백색분말

산도 계수 (pKa): 4.50±1.00(Predicted)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	22-41
안전지침서	26
WGK 독일	3
위험 등급	IRRITANT

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501
H318	눈에 심한 손상을 일으킴	심한 눈 손상 또는 자극성 물질	구분 1	위험		P280, P305+P351+P338, P310

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	0
3		0

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate C화학적 특성, 용도, 생산

개요

The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF_2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC₅₀ value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F_2α (PGF_2α) and PGE₂ production in human endometrial cells with an EC₅₀ value of 10 μM.

용도

A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate 준비 용품 및 원자재

원자재

준비 용품

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate 공급 업체

글로벌( 23)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7898	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Aikon International Limited	025-66113011 13155353615	qzhang@aikonchem.com	China	15396	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate 관련 검색:

1-BENZYL-1,5-DIHYDRO-PYRROL-2-ONE Ethyl 3-(benzylamino)propanoate 1-Benzyl-2,5-dihydro-1H-pyrrole 1-(4-Methoxybenzyl)-3-hydroxy-4-ethoxycarbonyl-5-(3-pyridyl)-3-pyrrolin-2-one ETHYL 3-(N-BENZYL-N-METHYLAMINO)PROPANOATE 1-BENZYL-2,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID METHYL ESTER ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate