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엘라골릭스

엘라골릭스 구조식 이미지

카스 번호:: 834153-87-6

한글명:: 엘라골릭스

동의어(한글):: 엘라골릭스

상품명:: elagolix

동의어(영문):: Elagoli;NBI 56418;(R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic acid;CS-2232;CS-2011;ABT-620;elagolix;Elagolix-d6;(R)-Elagolix;Elagolix CAS

CBNumber:: CB51518509

분자식:: C32H30F5N3O5

포뮬러 무게:: 631.59

MOL 파일:: 834153-87-6.mol

속성

안전

용도

공급 업체 196

엘라골릭스 속성

끓는 점: 728.6±70.0 °C(Predicted)

밀도: 1.350

저장 조건: Store at -20°C

용해도: DMSO : ≥ 100 mg/mL (158.33 mM)

산도 계수 (pKa): 4.40±0.10(Predicted)

물리적 상태: Solid

색상: White to off-white

InChIKey: HEAUOKZIVMZVQL-VWLOTQADSA-N

SMILES: C(O)(=O)CCCN[C@H](C1=CC=CC=C1)CN1C(=O)N(CC2=C(C(F)(F)F)C=CC=C2F)C(C)=C(C2=CC=CC(OC)=C2F)C1=O

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H360	태아 또는 생식능력에 손상을 일으킬 수 있음	생식독성 물질	구분 1A, 1B	위험

예방조치문구:

P201	사용 전 취급 설명서를 확보하시오.
P202	모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313	노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

엘라골릭스 C화학적 특성, 용도, 생산

개요

Elagolix is a gonadotropin-releasing hormone(GnRH) receptor antagonist indicated for the management of moderate to severe pain associated with endometriosis. Elagolix is an orally administered,nonpeptide small molecule gonadotropin-releasing hormone(GnRH) receptor antagonist that inhibits endogenousGnRH signaling by binding competitively to GnRH receptors in the pituitary gland.
Elagolix results in dose-dependent suppression of luteinizing hormone(LH) and follicle-stimulating hormone(FSH) leading to decreased blood leveis of the ovarian sex hormones, estradiol and progesterone.Elagolix causes a dose-dependent decrease in bone mineral density (BMD).BMD loss is greater with increasing duration of use and may not be completely reversible after stopping treatment.
As milk production is dependent on at least minimal levels of estrogen, this product may reduce milk production.

용도

Elagolix has a potential role for treating uterine bleeding associated to uterine myomas. Elagolix is also used in the methods for treatment of estrogen-dependent disorders including gonadotropin-releasing hormone (GnRH) antagonists in combination with add-back therapy.

제조 방법

Elagolix was a gonadotropin-releasing hormone antagonist. It was approved in 2018 by FDA via priority review for clinical treatment of endometriosis. Based on retrosynthetic analysis, five reported synthesis routes of elagolix were summarized. They were compared and evaluated in terms of step numbers, total yields, costs, synthetic conditions and manufacturing safety. At last, the synthetic method of d6-elagolix was introduced. This review would be beneficial to the future process researches of elagolix and its deuterium analogues.

Recent Progress in the Synthesis of Elagolix
Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor

엘라골릭스 준비 용품 및 원자재

원자재

4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]-, ethyl ester 3-[(2R)-2-Amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione Methyl 4-bromobutyrate

준비 용품

엘라골릭스 공급 업체

글로벌( 196)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Beijing Hope Pharmaceutical Co., Ltd.	+86-010-67886402 +8613611125266	market@hopelife.cn	China	71	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5856	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9210	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58

엘라골릭스 관련 검색:

(R)-2-(Boc-aMino)-2-phenylethyl 4-Methylbenzenesulfonate 1-[(1R)-2-hydroxy-1-phenylethyl]pyrrolidin-2-one Carbamic acid, N-[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester Elagolix Sodium 1-[2-fluoro-6-(trifluoromethyl)benzyl]-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione Ganirelix Ganirelix Acetate Relugolix Abarelix Cetrorelix acetate T-BUTYL 4-BROMOBUTYRATE 3-[(2R)-2-Amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 5-Bromo-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 2,2'-difluoro-3,3'-dimethoxy-1,1'-biphenyl Elagolix Sodium impurity4 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA 3-Bromo-2-fluoroanisole 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione