Δ4-다파크로닉산 C화학적 특성, 용도, 생산
개요
During unfavorable environmental conditions,
C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-
12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in
C. elegans. DAF-
12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ
4-
Dafachronic acid is a racemic version of a sterol-
derived hormone that acts as a ligand of DAF-
12. Δ
4-
Dafachronic acid binds to and transactivates DAF-
12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults. The (25S) diastereomer of Δ
4-
dafachronic acid is significantly more potent than its (25R) counterpart (EC
50s = 23 and 66 nM, respectively).
Δ4-다파크로닉산 준비 용품 및 원자재
원자재
준비 용품
