ChemicalBook >제품 카탈로그 >생화학 공학>억제제>세포 골격 신호>HSP 예 : HSP90 억제제>PF-04929113

PF-04929113

PF-04929113 구조식 이미지

카스 번호:: 908115-27-5

상품명:: PF-04929113

동의어(영문):: CS-33;snx54227;SNX-5422;PF-04929113;PF-04929113, >=98%;PF04929113 SNX-54227;PF-04929113(SNX5422);snx5422 PF 04929113;PF-04929113 USP/EP/BP;PF-04929113 SNX-5422 PF04929113 SNX5422

CBNumber:: CB52561489

분자식:: C25H30F3N5O4

포뮬러 무게:: 521.53

MOL 파일:: 908115-27-5.mol

속성

안전

용도

공급 업체 92

PF-04929113 속성

녹는점: 298-299℃

끓는 점: 646.5±55.0 °C(Predicted)

밀도: 1.48

저장 조건: Store at -20°C

용해도: ≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 15.07±0.50(Predicted)

색상: White to off-white

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	0
2		0

PF-04929113 C화학적 특성, 용도, 생산

용도

PF 04929113 can be used in pharmacological activity and therapeutic use in therapeutic breast cancer drug target for multiclass comparative virtual screening to identify novel Hsp90 inhibitors. HSP90

효소 저해제

This potent and selective HSP90 inhibitor (FW = 521.54 g/mol; CAS 908115-27-5; Solubility: 100 mg/mL DMSO, <1mg/mL H2O), also knownas SNX-5422 and (1R,4R)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3- (trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2- aminoacetate, targets heat shock protein-90 (Kd = 41 nM) and also inhibits Her-2 degradation (IC50 = 37 nM). PF-04929113 also shows potent antiproliferative activity against a broad range of cancer cell types, e.g. MCF-7 (IC50 =16 nM), SW620 (IC50 =19 nM), K562 (IC50 =23 nM), SK-MEL-5 (IC50 =25 nM), and A375 (IC50 =51 nM). SNX2112 inhibits in vitro proliferation, inducing G2/M arrest, and enhanced cytotoxicity, chemosensitivity, and radiosensitivity between 25 and 250 nM, decreasing expression and/or phosphorylation of EGFR, c-MET, AKT, ERK-1 and -2, IκB kinase, and STAT3, corresponding downstream NFκB, AP-1, and STAT3 reporter genes, and target oncogenes and angiogenic cytokines.

PF-04929113 준비 용품 및 원자재

원자재

준비 용품

PF-04929113 공급 업체

글로벌( 92)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32951	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32072	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	23025	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38466	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58

PF-04929113 관련 검색:

독소루비신 수화염화물 N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea 1 NM-PP1 BLU 9931 ZLN005 Esomeprazole magnesium Tariquidar Palbociclib IXABEPILONE L-4-THIAZOLYLALANINE Ilomastat AZD-1208 Crenolanib Selumetinib BIIB-021 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide Quizartinib (AC220) Fingolimod hydrochloride