21-하이드록시알로프레그나놀론
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21-하이드록시알로프레그나놀론 속성
- 녹는점
- >150oC (dec.)
- 저장 조건
- Refrigerator
- 용해도
- 클로로포름(약간 용해됨), 에탄올(약간 용해됨, 초음파처리), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
안전
WGK 독일 | 3 |
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21-하이드록시알로프레그나놀론 C화학적 특성, 용도, 생산
용도
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) has been used:- as an γ-aminobutyric acid type A receptor (γ-GABAA) agonist in voltage-clamp measurements studies in Xenopus oocytes
- to test its effect on the spike-wave discharges (SWD) finasteride-treated rats
- in electrophysiological studies with dentate granule cells (DGCs) post controlled cortical impact (CCI) -induced brain injury
일반 설명
3α21-Dihydroxy-5α-pregnan-20-one (THDOC) is a neurosteroid. It is synthesized in a two-step process from deoxycorticosterone (DOC) via 5α-dihydrodeoxycorticosterone (DHDOC) intermediate with enzymes 5α-reductase and 3α-hydroxysteroid oxidoreductase catalyzing these steps respectively.Biochem/physiol Actions
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) is a positive allosteric modulator of the γ-aminobutyric acid A receptor (GABAA). By modulating GABAA receptor, THDOC allows sustained hyperpolarization and an increase in chloride influx and membrane conductance in neurons. THDOC, thus modulates neuronal excitability. It possesses anxiolytic, anticonvulsant and sedative properties. The levels of THDOC show variation in different physiological states. A low THDOC level in the mensural phase is speculated to play a role in the pathogenesis of catamenial epilepsy (CE) in women. However, elevated levels are reported in depression. THDOC may have an indirect role in the hypothalamic-pituitary–adrenal (HPA) axis activation during acute stress.21-하이드록시알로프레그나놀론 준비 용품 및 원자재
원자재
준비 용품
21-하이드록시알로프레그나놀론 공급 업체
글로벌( 55)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 4088 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30253 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9624 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 |
sales@reading-chemicals.com | China | 15185 | 58 |
Finetech Industry Limited | 027-87465837 19945049750 |
sales@finetechnology-ind.com | China | 9619 | 58 |
21-하이드록시알로프레그나놀론 관련 검색:
Alphadolone
ALLOTETRAHYDRO S
3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
21-HYDROXYALLOPREGNANOLONE
5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE
ALLOTETRAHYDROCORTICOSTERONE
ALLOTETRAHYDROCORTISOL
5-ALPHA-PREGNAN-3-ALPHA, 11-BETA, 17,21-TETROL-20-ONE 3,21-DIACETATE
TETRAHYDRODEOXYCORTICOSTERONE
5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 3-ACETATE
5-ALPHA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 21-ACETATE
5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE DIACETATE
5ALPHA-PREGNANE-3ALPHA,21-DIOL-20-ONE (17,21,21-D3)
5-ALPHA-PREGNAN-3-ALPHA, 11-BETA, 21-TRIOL-20-ONE 3,21-DIACETATE
5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 21-STEARATE
5-ALPHA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3,21-DIACETATE
5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 21-ACETATE
5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 3-STEARATE