미네랄오일

미네랄오일 속성

미네랄오일 C화학적 특성, 용도, 생산

순도시험

  (1) 유리산 및 유리알칼리 : 이 품목 10mL에 열탕 약 10mL 및 페놀프탈레인시액 1방울을 가하여 심하게 흔들어 섞을 때, 홍색을 나타내어서는 아니 된다. 또 다시  0.02N 수산화나트륨용액 0.2mL를 가하여 흔들어 섞을 때, 홍색을 나타내어야 한다.

  (2) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

  (3) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

  (4) 다핵방향족탄화수소 : 이 품목 25mL를 25mL의 메스실린더에 취하여 100mL의 분액깔대기에 옮긴 다음 n-헥산 25mL를 가하고 잘 흔들어 섞는다. 이에 디메틸설폭시드 5mL를 가하여 2분간 심하게 흔들어 섞은 다음 15분간 정치한다. 하층을 50mL의 분액깔대기에 옮기고 n-헥산 2mL를 가하여 2분간 심하게 흔들어 섞은 다음 2분간 정치한다. 하층을 10mL 공전원심관에 옮겨 매분 2,500～3,000회전으로 약 10분간 원심분리한다. 여기서 얻은 징명한 액을 액층의 길이 1cm의 셀에 취하여 밀전하고 이를 시험용액으로 한다. 따로 n-헥산 25mL를 50mL 분액깔대기에 취하여 디메틸설폭시드 5mL를 가하고 2분간 심하게 흔들어 섞은 다음 2분간 정치한다. 하층을 10mL 공전원심관에 옮겨 매분 2,500～3,000회전으로 약 10분간 원심분리한다. 여기서 얻은 징명한 액을 액층의 길이 1cm의 셀에 취하여 밀전한 다음 이를 대조액으로 하여 즉시 시험용액의 흡광도를 측정할 때, 그 값은 260～350nm의 파장범위에서 0.1을 초과하여서는 아니 된다. 다만, 여기에서 사용하는 n-헥산 및 디메틸설폭시드는 자외부흡수스펙트럼측정용이어야 한다.

  (5) 황산정색물 : 이 품목 5mL를 네슬러관에 취하여 94.5～94.9% 황산 5mL를 가하고 수욕 중에서 2분간 가열한 다음 꺼내어 즉시 5초간 심하게 상하로 흔들어 섞는다. 이 조작을 계속 4회 되풀이할 때, 유동파라핀층은 변색하지 않는다. 또 황산층의 색은 염화제이철비색표준원액 3mL, 염화제일코발트비색표준원액 1.5mL 및 황산동비색표준원액 0.5mL를 네슬러관에 넣고 흔들어 준 액의 색보다 진하여서는 아니 된다.

확인시험

  (1) 이 품목을 자제접시에 취하여 점화하면 밝은 불꽃을 내고 타며 파라핀 증기의 특이한 냄새를 낸다.

  (2) 이 품목 약 0.5g에 같은 양의 황을 가하여 흔들어 섞은 다음 가열하면 황화수소의 냄새를 낸다.

정의

  이 품목은 석유에서 얻은 탄화수소류의 혼합물이다.

화학적 성질

Clear colorless oil

용도

Paraffin Oils is a useful organic solvent for isolating the nucleus of the gian amphibian oocyte.

생산 방법

Mineral oil is obtained by distillation of petroleum. The lighter hydrocarbons are first removed by distillation and the residue is then redistilled between 330–390°C. The distillate is chilled and the solid fractions are removed by filtration. The filtrate is then further purified and decolorized by high-pressure hydrogenation or sulfuric acid treatment; the purified filtrate is then filtered through adsorbents. The liquid portion obtained is distilled and the portion boiling below 360°C is discarded. A suitable stabilizer may be added to the mineral oil;

일반 설명

Transparent colorless oily liquid. Practically tasteless and odorless, even when warmed.

공기와 물의 반응

Flammable. Insoluble in water.

반응 프로필

OIL. [MINERAL] may be incompatible with strong oxidizing agents like nitric acid. Charring may occur followed by ignition of unreacted oil and other nearby combustibles. In other settings, mostly unreactive. Not affected by aqueous solutions of acids, alkalis, most oxidizing agents, and most reducing agents. Burns exothermically when heated sufficiently or when ignited in the presence of air, oxygen or strong oxidizing agents.

위험도

Inhalation of vapor or particulates can causeaspiration pneumonia. Combustible liquid. Upperrespiratory tract irritant. Questionable carcinogen.

건강위험

Highly refined mineral oil mist is of low toxicity.

화재위험

PARAFFIN is combustible.

Pharmaceutical Applications

Mineral oil is used primarily as an excipient in topical pharmaceutical formulations, where its emollient properties are exploited as an ingredient in ointment bases. It is additionally used in oil-in-water emulsions,as a solvent, and as a lubricant in capsule and tablet formulations, and to a limited extent as a mold-release agent for cocoa butter suppositories. It has also been used in the preparation of microspheres and as a vaccine adjunct.
Therapeutically, mineral oil has been used as a laxative.It is indigestible and thus has limited absorption. Mineral oil is used in ophthalmic formulations for its lubricant properties. It is also used in cosmetics and some food products.

Safety Profile

A human teratogen by inhalation that causes testicular tumors in the fetus. Inhalation of vapor or particulates can cause aspiration pneumonia. A skin and eye irritant. Highly purified food grades are of low toxicity. Questionable human carcinogen producing gastrointestinal tumors. Slightly combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2, foam. When heated to decomposition it emits acrid smoke and fumes.

저장

Mineral oil undergoes oxidation when exposed to heat and light. Oxidation begins with the formation of peroxides, exhibiting an ‘induction period’. Under ordinary conditions, the induction period may take months or years. However, once a trace of peroxide is formed, further oxidation is autocatalytic and proceeds very rapidly. Oxidation results in the formation of aldehydes and organic acids, which impart taste and odor. Stabilizers may be added to retard oxidation; butylated hydroxyanisole, butylated hydroxytoluene, and alpha tocopherol are the most commonly used antioxidants.
Mineral oil may be sterilized by dry heat.
Mineral oil should be stored in an airtight container, protected from light, in a cool, dry place.

Purification Methods

Treat the oil with fuming H2SO4 (care), then wash it with water and dilute aqueous NaOH, then percolate it through activated silica gel. Paraffin Wax. Melt the wax in the presence of NaOH, wash it with water until all of the base had been removed. The paraffin is allowed to solidify after each wash. Finally, 5g of paraffin is melted by heating it on a water-bath, then shaken for 20-30minutes with 100mL of boiling water and and dry the melt under vacuum.

비 호환성

Incompatible with strong oxidizing agents.

Regulatory Status

GRAS listed. Accepted in the UK for use in certain food applications. Included in the FDA Inactive Ingredients Database (dental preparations; IV injections; ophthalmic preparations; oral capsules and tablets; otic, topical, transdermal, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

미네랄오일 준비 용품 및 원자재

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미네랄오일 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12460	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21675	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Shanghai Longyu Biotechnology Co., Ltd.	+8613917842738	info@longyupharma.com	China	2534	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	2132	58

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