엠트리시타빈
|
|
엠트리시타빈 속성
- 녹는점
- 136-140°C
- 알파
- D25 -133.60° (c = 0.23 in MeOH)
- 끓는 점
- 443.3±55.0 °C(Predicted)
- 밀도
- 1.82±0.1 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- 클로로포름(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 13.83±0.10(Predicted)
- 색상
- 흰색에서 연한 노란색
- 최대 파장(λmax)
- 280nm(H2O)(lit.)
- Merck
- 14,3565
- BCS Class
- 1
- InChIKey
- XQSPYNMVSIKCOC-NTSWFWBYSA-N
- CAS 데이터베이스
- 143491-57-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
RTECS 번호 | UW7360500 | ||
---|---|---|---|
HS 번호 | 2934990002 | ||
유해 물질 데이터 | 143491-57-0(Hazardous Substances Data) |
그림문자(GHS): | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
신호 어: | Warning | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
|
|||||||||||||||||||||||||||||||||||
예방조치문구: |
|
엠트리시타빈 C화학적 특성, 용도, 생산
화학적 성질
White to Off-White Crystalline Solid용도
Labeled Emtricitabine, intended for use as an internal standard for the quantification of Emtricitabine by GC- or LC-mass spectrometry.정의
ChEBI: An organofluorine compound that is 5-fluorocytosine substituted at the 1 position by a 2-(hydroxymethyl)-1,3-oxathiolan-5-yl group (2R,5S configuration). It is used in combination therapy for the treatment of HIV-1 infect on.원료
Resistance is associated with a substitution in the HIV-1 reverse transcriptase gene at codon 184 (M184V/I). Emtricitabineresistant isolates are cross-resistant to lamivudine. HIV-1 isolates with the K65R substitution in the reverse transcriptase coding region have reduced susceptibility.일반 설명
Emtricitabine is an orally active NRTI whose pharmacokineticsare favorable for once-daily administration.Pharmaceutical Applications
A synthetic nucleoside analog of cytosine, formulated for oral use.Pharmacokinetics
Oral absorption: capsules 93%Cmax 200 mg oral once daily: 1.8 ± 0.7 mg/L
Plasma half-life: c. 10 h
Volume of distribution: 1.4 ± 0.3 L/kg
Plasma protein binding: <4%
Absorption and distribution
It is rapidly and extensively absorbed. There is moderate CNS penetration. The estimated semen:plasma ratio is approximately 4. There are presently no data on levels in breast milk.
Metabolism and excretion
It does not inhibit human cytochrome P450 enzymes. About 80% is excreted in the urine, the rest in feces. Renal clearance is greater than the estimated creatinine clearance, suggesting elimination by both glomerular filtration and active tubular secretion. There may be competition for elimination with other compounds that are renally excreted. Exposure is significantly increased in renal insufficiency, but dose reductions are not generally recommended. It is unlikely that a dose adjustment would be required in the presence of hepatic impairment.
Clinical Use
Treatment of HIV infection (in combination with other antiretroviral drugs)부작용
At least 10% of patients suffer headache, diarrhea, nausea, fatigue, dizziness, depression, insomnia, abnormal dreams, rash, abdominal pain, asthenia, increased cough and rhinitis. Skin hyperpigmentation is common (≥10%) in pediatric patients. Emtricitabine competes with lamivudine for the enzymes involved in intracellular phosphorylation; their co- administration is contraindicated.엠트리시타빈 준비 용품 및 원자재
원자재
준비 용품
엠트리시타빈 공급 업체
글로벌( 612)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
admin@oudaxin.com | China | 399 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1142 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9338 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
career henan chemical co | +86-0371-86658258 15093356674; |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
엠트리시타빈 관련 검색:
트리스(하이드록시메틸)니트로메탄 트리스(하이드록시메틸)아미노메탄 글리신 6-아미노 카프로산 시토신 플루시토신 프라세오디뮴(III) 트리스[3-(트리플루오로메틸하이드록시메틸렌)-d-캠포레이트] 플루오린(불소) 라미부딘
ALTRENOGEST
(-)-EMtricitabine S-Oxide
(Mixture of DiastereoMers)
[1R-[1(2S*,5R*),2beta,5alpha]]-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid 5-methyl-2-(1-methylethyl)cyclohexyl ester
(-)-FTC-13C,15N2,EMTRICITABINE-13C,15N2
Emtricitabine Impurity
Emtricitabine Impurity 18
(2S)-2-[[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]-1,3-oxathiolan-5-ol 5-Acetate
(2R,5S)-5-(5-Fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
(+)-NEOMENTHOL