2-Amino-4-bromo-3-fluorobenzoic acid
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2-Amino-4-bromo-3-fluorobenzoic acid 속성
- 끓는 점
- 332.0±42.0 °C(Predicted)
- 밀도
- 1.877±0.06 g/cm3(Predicted)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2–8 °C
- 산도 계수 (pKa)
- 4.37±0.10(Predicted)
- 물리적 상태
- 가루
- 색상
- 오프 화이트
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 2922498590 |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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2-Amino-4-bromo-3-fluorobenzoic acid C화학적 특성, 용도, 생산
개요
2-Amino-4-bromo-3-fluorobenzoic acid is an important pharmaceutical and organic intermediate ingredient used in the synthesis of avibactam sodium, an FDA-approved non-beta-lactam β-lactamase inhibitor used in combination with ceftazidime (Avycaz). It is used for the treatment of complicated intra-abdominal infections, urinary tract infections, and pyelonephritis.용도
2-Amino-4-Bromo-3-Fluorobenzoic Acid is used in preparation of Quinazoline compounds as KRAS modulators and antitumor agents.Synthesis
The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
2-Amino-4-bromo-3-fluorobenzoic acid 준비 용품 및 원자재
원자재
준비 용품
2-Amino-4-bromo-3-fluorobenzoic acid 공급 업체
글로벌( 162)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| WinWin Chemical CO., Limited | +86-0577-64498589 +8615325081899 |
sales@win-winchemical.com | China | 14197 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
| Zjartschem | +86-571 87238903 |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 |
sales@win-winchemical.com | CHINA | 998 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10318 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7353 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2967 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |