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인디

인디 구조식 이미지

카스 번호:: 1169755-45-6

한글명:: 인디

동의어(한글):: 인디

상품명:: INDY

동의어(영문):: INDY;(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone;(1Z)-1-(3-Ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)acetone;(1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one;(Z)-1-(3-Ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;2-Propanone, 1-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-, (1Z)-

CBNumber:: CB52748091

분자식:: C12H13NO2S

포뮬러 무게:: 235.3

MOL 파일:: 1169755-45-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 59

인디 속성

끓는 점: 409.2±45.0 °C(Predicted)

밀도: 1.337±0.06 g/cm3(Predicted)

저장 조건: -20°C

용해도: DMSO: 용해성5mg/mL, 투명(가온)

산도 계수 (pKa): 9.67±0.20(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

WGK 독일	3

인디 C화학적 특성, 용도, 생산

개요

INDY is an ATP-competitive inhibitor of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A; K_i = 180 nM; IC₅₀ = 240 nM). It is selective for DYRK1A over monoamine oxidase (MAO) A and B at concentrations up to 100 μM. INDY inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner. It also restores signaling through nuclear factory of activated T cells (NFAT) and NFAT-dependent transcription in HEK293 cells overexpressing DYRK1A. In vivo, INDY reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos. INDY also induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro.

용도

INDY is a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A/B (DYRK1A/B) inhibitor (1,2).

인디 준비 용품 및 원자재

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준비 용품

인디 공급 업체

글로벌( 59)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4197	55
Guangzhou Zhiya Chemdrugs Co.,Ltd	18122150900	sculk28@163.com	China	646	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
TaiChem Taizhou Limited	052386810091	zcwy9518@yeah.net	China	3875	58
Shanghai Changyan Chem & Tech Co., Ltd.	021-021-20242659 18930833303	order@changyanchem.com	China	5008	55