4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide
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4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide 속성
- 저장 조건
- Store at -20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- Solid
- 색상
- White to off-white
안전
4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide C화학적 특성, 용도, 생산
Biochem/physiol Actions
AZ12799734 is an orally active TGF-β type I receptors active site inhibitor (ALK1/2/3/4/5/6 Kd = 7.1/6.2/40/1/0.74/0.017 μM) that inhibits ALK5-dependent Smad2 nuclear translocation upon TGF-β1 stimulation (IC50 = 17 nM; MDA-MB-468), as well as ALK1/2/3/6-mediated Smad1 and ALK4/5/7-mediated Smad2 phosphorylation (10 μM; NIH3T3 expressing respective constitutively active receptors). AZ12799734 oral administration in rats results in heart valve lesions (200 mg/kg/day for 5 days) and physeal dysplasia (400 mg/kg/day for 6 days), consistent with a critical role of ALK5 in maintaining the integrity of heart valve and physis.4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide 준비 용품 및 원자재
원자재
준비 용품
4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide 공급 업체
글로벌( 10)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 |
huahero21@sina.com | China | 384 | 55 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 |
sales@glpbio.cn | China | 6870 | 58 |
Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 |
3477467573@qq.com | China | 8618 | 58 |
TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 23963 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 |
sales@chemhifuture.com | China | 4565 | 58 |
Shaanxi Istare Biotechnology Co., Ltd. | 18682931470 |
2142355700@qq.com | China | 2667 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 |
cindy.huang@synzest.com | China | 12007 | 58 |