E3 ligase Ligand-Linker Conjugates 5

E3 ligase Ligand-Linker Conjugates 5 구조식 이미지
카스 번호:
2097971-11-2
상품명:
E3 ligase Ligand-Linker Conjugates 5
동의어(영문):
VH032-PEG3-NH2 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride;E3 ligase Ligand-Linker Conjugates 5;(S,R,S)-AHPC-PEG3-NH2 hydrochloride >=95%;VHL Ligand-Linker Conjugates 1 hydrochloride;(S,R,S)-AHPC-PEG3-NH2 hydrochloride(E3 ligase Ligand-Linker Conjugates 5);(S,R,S)-AHPC-PEG3-NH2 hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2R,4S)-1-((R)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
CBNumber:
CB53386472
분자식:
C30H46ClN5O7S
포뮬러 무게:
656.24
MOL 파일:
2097971-11-2.mol
MSDS 파일:
SDS

E3 ligase Ligand-Linker Conjugates 5 속성

저장 조건
2-8°C
물리적 상태
분말 또는 결정
색상
Light yellow to brown

안전

HS 번호 2934100090

E3 ligase Ligand-Linker Conjugates 5 C화학적 특성, 용도, 생산

용도

Protein degrader builiding block (S,R,S)-AHPC-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 5 준비 용품 및 원자재

원자재

준비 용품


E3 ligase Ligand-Linker Conjugates 5 공급 업체

글로벌( 39)공급 업체
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TargetMol Chemicals Inc.
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Aladdin Scientific

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Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860
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Sigma-Aldrich 021-61415566 800-8193336
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Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903
3008007409@qq.com China 71826 60

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