Silymarin

Silymarin 속성

Silymarin C화학적 특성, 용도, 생산

용도

Silymarin a flavonolignan complex extracted from milk thistle, has been shown to provide cytoprotective, antioxidant and hepatoprotective effects. Provides extracts such as (+)-taxifolin as an inhibitor of β-amyloid aggregation.

Indications

Milk thistle (Silybum [Carduus] marianus) is a spiny European plant with white-veined leaves and milky sap, the seed of which is used to treat liver disease.Milk thistle seed extract is used orally in the treatment of alcoholic and other cirrhoses and in Europe intravenously for its hepatoprotective effect in Amanita and other mushroom poisonings. It is grown in this country primarily as a “liver cleanser” and is reputed to protect this organ from a wide array of toxins.Milk thistle seed contains the active principle silymarin, a complex of flavonolignan compounds including silibinin (silybin), silidianin, and silychristin.

일반 설명

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Mechanism of action

Silymarin is thought to protect the liver by preventing the entry of toxins into the hepatocyte and by stimulating nucleolar polymerase A, which, in turn, increases protein synthesis and liver regeneration. Silymarin undergoes enterohepatic circulation, increasing its concentration in hepatocytes. It is also an antioxidant in its own right and is considered to have some cytoprotective effect against carcinogens.

Clinical Use

Alcoholic cirrhosis has been improved (faster return of liver enzymes to baseline) in at least three trials, although one multicenter Spanish study failed to demonstrate any change in the clinical course.There is no evidence to support the use of milk thistle to increase alcohol tolerance, although it is certainly being used for this purpose. The effectiveness of silymarin for viral hepatitis is not clear, although several trials demonstrated enough benefit to encourage further studies.
Intravenous silymarin has been demonstrated to lower mortality from Amanita mushroom poisonings, but this formulation is available only in Europe.Animal studies have demonstrated hepatic protection against alcohol, acetaminophen, and mushroom toxins and protection against hepatic fibrosis with bile duct occlusion. There is also evidence of silybin protecting against cisplatin- induced nephrotoxicity in rats. It is not yet clear whether milk thistle extract offers any renal protection to humans.

부작용

Milk thistle appears to be remarkably safe, with loose stools due to increased bile solubility and occasional allergic reactions being the common side effects. It has not been evaluated in children or in pregnant women.There are no known serious drug or herb interactions.

Silymarin 준비 용품 및 원자재

원자재

준비 용품

Silymarin 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Xi'an ZB Biotech Co.,Ltd	+8618591943808	sales01@xazbbio.com	China	815	58
Lewoo Pharmatech(Shanghai)Co.,Ltd	+86-15800805830 +86-15800805830	miao@lewoopharma.com.cn	China	184	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
ZhenYiBio Technology Inc	+8615309206328	alexxue@zhenyibio.com	China	296	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	430	58
Aurora Industry Co., Ltd.	+86-13591747876 +86-13591747876	alex1_auco@126.com	China	299	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	3712	58

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