2,5-디클로로-4,6-디메틸니코티노니트릴
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2,5-디클로로-4,6-디메틸니코티노니트릴 속성
- 녹는점
- 82 °C
- 끓는 점
- 304.6±37.0 °C(Predicted)
- 밀도
- 1.36
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- -2.79±0.10(Predicted)
- 색상
- 하얀색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-36/37/38 | ||
| 안전지침서 | 26-36/37/39 | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 2933399990 |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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2,5-디클로로-4,6-디메틸니코티노니트릴 C화학적 특성, 용도, 생산
용도
2,5-Dichloro-4,6-dimethyl-3-pyridinecarbonitrile, can be used for the synthesis of a selective muscarinic receptor 4 (M4) positive allosteric modulator called ML253, which is a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.Synthesis
Phosphoryl chloride (973.2g), tetramethylammonium chloride (67.3g) and compound of Preparation 2 (227.1g) were added to dichloromethane (500g). The suspension was heated to 85°C and stirred for 5 hours. Excess of phosphoryl chloride was removed by distillation in vacuo. The reaction mixture was cooled below 30 °C and diluted with dichloromethane. The resulting solution was added to water (1350g) at room temperature and stirred for 30 minutes. The lower organic phase was separate and the aqueous phase extracted with dichloromethane. The organic phases were combined, washed with water and then treated with charcoal. The charcoal was filtered and a solvent swap to heptane was performed by distillation at atmospheric pressure. The solution was filtered at 50 °C and then cooled to 30 °C. On further cooling to 0°C crystals were obtained. These were isolated by filtration, washed twice with heptane. After drying at 50°C the desired product was obtained typically at 88-91 % . The above process was repeated with a reduction in dichloromethane during crystallisation and adding some methanol. The resulting plate-like crystals were more easily transferred for subsequent use.
2,5-디클로로-4,6-디메틸니코티노니트릴 준비 용품 및 원자재
원자재
준비 용품
2,5-디클로로-4,6-디메틸니코티노니트릴 공급 업체
글로벌( 171)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 |
sales@fluoropharm.com | China | 1377 | 60 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 |
sales@win-winchemical.com | CHINA | 998 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10318 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 |
sales@worldyachem.com | China | 1080 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 |
info@edengenechem.com | China | 2169 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 |
CHINA | 514 | 58 |
2,5-디클로로-4,6-디메틸니코티노니트릴 관련 검색:
3-시아노피린딘
5-CHLORO-3-CYANOPYRIDINE
2-Chloro-4-methylpyridine-3-carbonitrile
2-Chloro-6-methyl-3-pyridinecarbonitrile
4,6-DIMETHYLNICOTINONITRILE
3-CHLORO-5-METHYLPYRIDINE
3-CHLORO-2-METHYLPYRIDINE
3-CHLORO-4-METHYLPYRIDINE
2-Chloro-3-cyano-4,6-dimethylpyridine
2-Chloro-3-cyanopyridine
3-Cyano-4-methylpyridine
2,5-DICHLORO-4,6-DIMETHYLNICOTINONITRILE
2,5-Dichloropyridine
2,5-DICHLORO-3-PICOLINE
2-Chloro-3-picoline
6-Chloro-2-picoline
2,5-DICHLORO-4-METHYLPYRIDINE
2-Chloro-4-picoline