타크린염산염
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타크린염산염 속성
- 녹는점
- 280-284 °C(lit.)
- 저장 조건
- Inert atmosphere,2-8°C
- 용해도
- 수성 완충액에 용해됨
- 산도 계수 (pKa)
- pKa 9.8 (Uncertain)
- 물리적 상태
- 결정질 고체
- 색상
- White to light yellow
- CAS 데이터베이스
- 1684-40-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 25-36/37/38-20/22 | ||
안전지침서 | 26-36-45 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | AR9532500 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
독성 | LD50 intravenous in mouse: 5600ug/kg |
타크린염산염 C화학적 특성, 용도, 생산
개요
Tacrine is the first therapeutic launched specifically for the treatment of Alzheimer's disease which affects four million people in the US alone. Clinically significant improvement in cognition has been demonstrated in the patients with Alzheimer's disease. Although the cause of Alzheimer's disease is not understood, degeneration of cholinergic neurons is thought to be a primary factor in the development and progression of the disease. Tacrine is a reversible acetylcholinesterase inhibitor that presumably acts centrally by elevating the acetylcholine level in the cerebral cortex and by slowing degradation of acetylcholine from intact cholinergic neurons. While tacrine improves the symptoms of Alzheimer's disease, the underlining cause of the dementing process is not altered. It has also been suggested that the beneficial effects of tacrine may be due to its multiple effects on several neurotransmitter systems.화학적 성질
Pale Yellow Solid용도
A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholi일반 설명
Tacrine hydrochloride,1,2,3,4-tetrahydro-9-aminoacridine hydrochloride (THA,Cognex), is a reversible cholinesterase inhibitor that hasbeen used in the treatment of Alzheimer disease for severalyears. The drug has been used to increase the levels of AChin these patients on the basis of observations from autopsiesthat concentrations of ChAT and AChE are markedly reducedin the brain, whereas the number of muscarinic receptorsis almost normal. The use of the drug is not withoutcontroversy, as conflicting results on efficacy have been reported.The drug has been used in mild-to-moderateAlzheimer dementia.공기와 물의 반응
Water soluble.반응 프로필
TACRINE HYDROCHLORIDE is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides . Neutralize bases in slightly exothermic reactions.화재위험
Flash point data for TACRINE HYDROCHLORIDE are not available; however, TACRINE HYDROCHLORIDE is probably combustible.생물학적 활성
Potent cholinesterase inhibitor, a cognition enhancer in vivo .신진 대사
Tacrine is extensively metabolized by CYP450 to at least three metabolites. The major metabolite, 1-hydroxy-tacrine, is active. Its elimination half-life is between 1.5 and 4 hours, with metabolites being are excreted via the urine.타크린염산염 준비 용품 및 원자재
원자재
준비 용품
타크린염산염 공급 업체
글로벌( 121)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 |
marketing1@neostarunited.com | China | 11006 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 8853 | 58 |
CD Chemical Group Limited | +8615986615575 |
info@codchem.com | China | 20356 | 58 |
Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 |
Lingzhiyue@aliyun.com | China | 3152 | 58 |
타크린염산염 관련 검색:
2',6'-DiMethylcarbonylphenyl-10-sulfopropylacridiniuM-9-carboxylate 4'-NHS Ester
Butyrylcholinesterase
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
TACRINE HYDROCHLORIDE
6,7-DICHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-AMINE
5-Chloro-1,2,3,4-tetrahydro-9-morpholinoacridine hydrochloride
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HCL HYDRATE
Centbucridine
BIS(7)-TACRINE
9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE
TACRINE HYDROCHLORIDE HYDRATE
9-AMINO-6-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE
9-AMINO-6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROACRIDIN-1(2H)-ONE
1-Acridinol, 1,2,3,4-tetrahydro-6-chloro-9-((phenylmethyl)amino)-
1,2,3,4-Tetrahydro-9-((2-(bis(2-chloroethyl)amino)ethyl)amino)acridine dihydrochloride
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE BIS 1,7-HEPTYLENE DIHYDROCHLORIDE
9-AMINO-6-CHLORO-3,4-DIHYDROACRIDIN-1(2H)-ONE
1,2,3,4-TETRAHYDRO-6-CHLORO-9-(N-D,L-ALPHA-LIPOOYLANIDOPROPYL)-AMINO-ACRIDINE