PYRANTEL

PYRANTEL C화학적 특성, 용도, 생산

용도

Pyrantel is a highly effective antihelmintic drug for enterobiasis, ascardiasis, ankylostomiasis, and necatoriasis. The antihelmintic effect is exhibited in the form of a powerful cholinomimetic effect on muscle cells of nematodes by binding with their cholinergic receptors, which leads to inhibition of neuromuscular transmission in the parasite, contraction of their musculature, and as a result, in the removal of the helminthes from the gastrointestinal tract of the host. It heals 85–100% of cases of ascariasis, and 90–100% of cases of enterobiasis. It is the drug of choice for Enterobius vermicularis, Acaris lumbricoides, as well as Ancylostoma duodenale, and Necator americanus. Synonyms of this drug are helmex, combantrin, antiminth, and others.

Pharmaceutical Applications

A tetrahydropyrimidine, formulated as the pamoate (embonate) in a 1:1 ratio and available as a suspension for oral administration. It is practically insoluble in water, but soluble in dimethyl sulfoxide. It is stable at room temperature.

Pharmacokinetics

By synthetic design most of the dose is passed unchanged in the feces. The portion that is absorbed (<5%) is metabolized and excreted in the urine.

Clinical Use

Ascariasis
Pinworm
Hookworm (especially A. duodenale)
Trichostrongyliasis
Higher and more prolonged doses may be necessary in hookworm infection caused by N. americanus. Pyrantel has been used in combination with an analog (oxantel) where concurrent whipworm infection was likely.

부작용

Pyrantel should not be used at the same time as piperazine as their modes of action are antagonistic. Gastrointestinal upsets and, rarely, very mild neurological symptoms occur.

PYRANTEL 준비 용품 및 원자재

원자재

준비 용품

PYRANTEL 공급 업체

공급자	전화	이메일	국가	제품 수	이점
SynZeal Research Pvt Ltd	--	standards@synzeal.com	India	6522	58
Lanospharma Laboratories Co.,Ltd	--	sales@lanospharma.com	China	6343	56
kemikalieimport	--	Sales@kemikalieimport.dk	Europe	6699	47