4-히드록시-템포
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4-히드록시-템포 속성
- 녹는점
- 69-71 °C(lit.)
- 끓는 점
- 302.58°C (rough estimate)
- 밀도
- 1.0402 (rough estimate)
- 증기압
- 0.025Pa at 20℃
- 굴절률
- 1.4350 (estimate)
- 인화점
- 146°(295°F)
- 저장 조건
- 2-8°C
- 용해도
- 1670g/l
- 물리적 상태
- 결정 또는 결정성 분말
- 산도 계수 (pKa)
- 5.07[at 20 ℃]
- 색상
- 오렌지 레드
- 색상
- 오렌지색
- 수소이온지수(pH)
- 8.2 (20g/l, H2O, 20℃)
- 수용성
- 녹는
- Merck
- 14,9141
- BRN
- 1422990
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- FAPCFNWEPHTUQK-UHFFFAOYSA-N
- LogP
- 0.56 at 25℃
- CAS 데이터베이스
- 2226-96-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-36/38 | ||
안전지침서 | 26-36-37/39-36/37/39-27 | ||
WGK 독일 | 1 | ||
RTECS 번호 | TN8991000 | ||
TSCA | Yes | ||
HS 번호 | 29333999 | ||
유해 물질 데이터 | 2226-96-2(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 1053mg/kg | ||
기존화학 물질 | KE-20899 |
4-히드록시-템포 C화학적 특성, 용도, 생산
개요
TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.화학적 성질
solid용도
A free radical scavenger주요 응용
In biochemical research, 4-hydroxy-TEMPO has been investigated as an agent for limiting reactive oxygen species. It catalyzes the disproportionation of superoxide, facilitates hydrogen peroxide metabolism, and inhibits Fenton chemistry.4-Hydroxy-TEMPO, along with related nitroxides, are being studied for their potential antioxidant properties.On an industrial-scale 4-hydroxy-TEMPO is often present as a structural element in hindered amine light stabilizers, which are commonly used stabilizers in plastics, it is also used as a polymerisation inhibitor, particularly during the purification of styrene.일반 설명
4-Hydroxy-TEMPO is a 4-substituted 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) derivative. It is a low-molecular weight compound and has been proposed as superoxide dismutase mimic.생물학적 활성
Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.4-히드록시-템포 준비 용품 및 원자재
원자재
준비 용품
4-히드록시-템포 공급 업체
글로벌( 564)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Jiangxi Lotchem Co.,Ltd. | +8615270827708 |
lancetu@jxlotchem.com | CHINA | 338 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2967 | 58 |
ZHEJIANG ESTCHEM CO.,LTD | 15957180504 |
sales@zjestchem.com | China | 193 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Yujiang Chemical (Shandong) Co.,Ltd. | +86-17736087130 +86-18633844644 |
catherine@yjchem.com.cn | China | 978 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +8613288715578 |
angelia@hbmojin.com | China | 830 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 |
admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16914 | 58 |
4-히드록시-템포 관련 검색:
할로페리돌 2,2,6,6-사메틸-4-피페리디놀 2,2,6,6-사메틸-4-(메틸설포닐 옥시)-1-피페리디노 옥시, 자유 라디칼 4-히드록시-템포 벤조산염,라디칼 4-히드록시-템포
CHLOROPHOSPHONAZO III
1,2,2,6,6-Pentamethyl-4-piperidinol
Drag-reduction agent
Triacetonediamine
2,2,6,6-Tetramethylpiperidine
Diethyl bis(2-hydroxyethyl)aminomethylphosphonate
9,10-Dihydro-9-oxa-10-phosphaphenanthrene 10-oxide
9,10-Dihydro-10-(2,3-dicarboxypropyl)-9-oxa-10-phosphaphenanthrene 10-oxide
Octabenzone
Piperazine-2-carboxylic acid dihydrochloride
Tri(4-isopropylphenyl) phosphate
3-Hydroxyphenylphosphinyl-propanoic acid
Triphenyl phosphate