올레속심

올레속심
올레속심 구조식 이미지
카스 번호:
22033-87-0
한글명:
올레속심
동의어(한글):
올레속심
상품명:
Olesoxime
동의어(영문):
TRO19266;NSC 21311;olesoxime;TRO 19622;Olesoxime (TRO-19622);Cholest-4-en-3-one oxime;OLESOXIME;NSC 21311;TRO19622;TRO-19622;Cholest-4-en-3-one, oxime, NSC 21311;Inhibitor,NSC21311,NSC-21311,TRO19622,Olesoxime,inhibit,TRO-19622,Mitochondrial Metabolism;(NE)-N-[10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,6,7,8,9,11,12,14,1 5,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
CBNumber:
CB61254361
분자식:
C27H45NO
포뮬러 무게:
399.65
MOL 파일:
22033-87-0.mol
MSDS 파일:
SDS

올레속심 속성

녹는점
145-148 ºC
끓는 점
510.0±23.0 °C(Predicted)
밀도
1.10
저장 조건
-20°C
용해도
DMSO: >10mg/mL
산도 계수 (pKa)
12.27±0.70(Predicted)
물리적 상태
고체
물리적 상태
단단한 모양
색상
하얀색
안정성
최대 3개월 동안 -20°C에서 DMSO 또는 에탄올에 보관
CAS 데이터베이스
22033-87-0(CAS DataBase Reference)

안전

WGK 독일 3

올레속심 C화학적 특성, 용도, 생산

용도

TRO 19622 interacts with mitochondria proteins and is able to promote neuron survival under stress conditions. It is a potential drug for treating amyotrophic lateral sclerosis (ALS). TRO 19622 is a neuroregenerative and neuroprotective agent. This is a research product for neuroscience.

생물학적 활성

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo . Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein.

Biochem/physiol Actions

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.

올레속심 준비 용품 및 원자재

원자재

준비 용품


올레속심 공급 업체

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