스핑가닌
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스핑가닌 속성
- 녹는점
- 70-72°C
- 끓는 점
- 446.2±25.0 °C(Predicted)
- 밀도
- 0.927±0.06 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- 클로로포름/메탄올(9:1): 20mg/mL, 투명, 무색 ~ 희미한 노란색
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 12.57±0.45(Predicted)
- 색상
- 하얀색
- 수용성
- 물에 용해됨(일부 혼화성), 클로로포름, 100% 따뜻한 에탄올(25mg/ml), 따뜻한 DMSO(25mg/ml) 및 메탄올.
- InChI
- InChI=1/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/s3
- InChIKey
- OTKJDMGTUTTYMP-LHIQYTEENA-N
- SMILES
- C(O)[C@@H](N)[C@@H](O)CCCCCCCCCCCCCCC |&1:2,4,r|
- CAS 데이터베이스
- 3102-56-5(CAS DataBase Reference)
안전
WGK 독일 | 3 |
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스핑가닌 C화학적 특성, 용도, 생산
개요
DL-erythro Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate . Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers. This product is a mixture of sphinganine (d18:0) , L-erythro sphinganine (d18:0) , D-threo sphinganine (d18:0) , and L-threo sphinganine (d18:0). [Matreya, LLC. Catalog No. 1324]화학적 성질
White Powder용도
DL-erythro-Dihydrosphingosine is an inhibitor of PKC (protein kinase C). This compound also blocks PLA2 (phospholipases A2) and the D-sphingosine precursor.Biological Functions
Sphingosine (Sph) is emerging as an intracellular regulator of cellular differentiation and apoptosis. Three stereoisomers,d-erythro-Sph,l-threo-Sph, and dl-erythro-dihydrosphingosine, were tested in the induction of apoptosis and inhibition of MAPK activity in three different kinds of solid tumour cell lines. d-erythro-Sph was strongest in these effects among the three compounds. l-threo-Sphingosine was partly active. On the other hand,dl-erythro-dihydrosphingosine was inactive[1].생물학적 활성
Protein kinase C inhibitor.Purification Methods
Purify it by recrystallisation from pet ether/EtOAc or CHCl3. The (±)-N-dichloroacetyl derivative has m 142-144o (from MeOH). [Shapiro et al. J Am Chem Soc 80 2170 1958, Shapiro & Sheradsky J Org Chem 28 2157 1963.] The D-isomer crystallises from pet ether/Et2O and has m 78.5-79o, [] 28 +6o (CHCl3/MeOH, 10:1). [Grob & Jenny Helv Chim Acta 35 2106 1953, Jenny & Grob Helv Chim Acta 36 1454 1953, Beilstein 4 I 448, 4 II 757, 4 III 854, 4 IV 1887.]스핑가닌 준비 용품 및 원자재
원자재
준비 용품
스핑가닌 공급 업체
글로벌( 74)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 |
sales@zhswyy.com | China | 301 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 |
1057@dideu.com | China | 3921 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10312 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 24330 | 58 |
Alfa Chemistry | |
Info@alfa-chemistry.com | United States | 24072 | 58 |
Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 |
sales@anikare.com | China | 9257 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 |
sale@mainchem.com | China | 32360 | 55 |
스핑가닌 관련 검색:
N-(6-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]CAPROYL)-PHYTOSPHINGOSINE
Phytosphingosine
C2 DIHYDROCERAMIDE
C14 Dihydroceramide
DL-ERYTHRO-DIHYDROSPHINGOSINE
C12 NBD-L-THREO-DIHYDROSPHINGOSINE
C6 NBD-D-ERYTHRO-DIHYDROSPHINGOSINE
C6 NBD-L-THREO-DIHYDROSPHINGOSINE
C12 NBD-D-ERYTHRO-DIHYDROSPHINGOSINE
D-ERYTHRO-SPHINGOSINE
D-erythro-Dihydro-D-sphingosine-1-phosphate
C6 DIHYDROCERAMIDE
KRN7000
C8 DIHYDROCERAMIDE
C6 NBD SAFINGOL
C18 Dihydroceramide
C4 Dihydroceramide
N-[12-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]DODECANOYL]-SPHINGANINE