4-클로로벤지드릴 알코올

4-클로로벤지드릴 알코올
4-클로로벤지드릴 알코올 구조식 이미지
카스 번호:
119-56-2
한글명:
4-클로로벤지드릴 알코올
동의어(한글):
4-클로로벤지드릴알코올
상품명:
4-Chlorobenzhydrol
동의어(영문):
Chlorobenzhydrol;Cetirizine 4-Chlorobenzhydrol Impurity;AURORA KA-7061;4-CHLOROBENZHYDROL;Meclizine USP RC A;P-CHLORO BENZHYDROL;4-Chlorobenzohydrol;p-Chlorobenzohydrol;Benzhydrol, p-chloro-;Benzhydrol, 4-chloro-
CBNumber:
CB6151432
분자식:
C13H11ClO
포뮬러 무게:
218.68
MOL 파일:
119-56-2.mol
MSDS 파일:
SDS

4-클로로벤지드릴 알코올 속성

녹는점
58-60 °C (lit.)
끓는 점
150-151°C 2,6mm
밀도
1.1178 (rough estimate)
굴절률
1.5260 (estimate)
인화점
150-151°C/2.6mm
저장 조건
2-8°C
용해도
불용성
산도 계수 (pKa)
13.34±0.20(Predicted)
색상
흰색에서 황백색까지
수용성
불용성
BRN
2050235
CAS 데이터베이스
119-56-2(CAS DataBase Reference)
NIST
Benzenemethanol, 4-chloro-«alpha»-phenyl-(119-56-2)
EPA
Benzenemethanol, 4-chloro-.alpha.-phenyl- (119-56-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 20/21/22-36/37/38
안전지침서 24/25-36-26
WGK 독일 3
TSCA Yes
HS 번호 29062990
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
예방조치문구:
P273 환경으로 배출하지 마시오.
P501 ...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
1 0

4-클로로벤지드릴 알코올 C화학적 특성, 용도, 생산

화학적 성질

white crystalline powder

용도

4-Chlorobenzhydrol was used as internal standard to measure the N-demethyl antipyrine metabolite in urine by gas chromatography-mass spectrometry. It was also used in the identification of the antihistamine cetirizine as a relevant cross-reactant for the carbamazepine-specific enzyme-linked immunosorbent assay .

제조 방법

Preparation of 4-Chlorobenzhydrol(4-CB):
about 5.0g(0.023 mol) of 4-chloro benzophenone was dissolved in 15 mL of isopropyl alcohol (IPA) and heated to 50°C followed by the addition of 0.265g(0.007 mol) of sodium borohydride as a lot with the temperature maintained at 65°C for 2 h. The reaction mixture was distilled to expel isopropyl alcohol up to 90 %. The resulting solution was cooled and treated with dil HCl (5 mL of conc. HCl in 20 mL of water). Finally the reaction mass was extracted with 15 mL of toluene. The toluene extract was washed withwater to pH-7. The compound obtained in this step was taken to next step without isolation but aliquot sample was concentrated, isolated and checked for melting point (m.p. = 58-60°C).

4-클로로벤지드릴 알코올 준비 용품 및 원자재

원자재

준비 용품


4-클로로벤지드릴 알코올 공급 업체

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