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FR122047염산염

FR122047염산염 구조식 이미지

카스 번호:: 130717-51-0

한글명:: FR122047염산염

동의어(한글):: FR122047염산염

상품명:: FR 122047 HYDROCHLORIDE

동의어(영문):: FR 122047;FR122047HCl;FR 122047 HYDROCHLORIDE;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine;5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone HCl;[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-(4-methyl-1-piperazin-4-iumyl)methanone;1-[(4,5-BIS(4-METHOXYPHENYL)-2-THIAZOYL)CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;4,5-BIS(4-METHOXYPHENYL-2-[(1-METHYLPIPERAZIN-4-YL)CARBONYL]THIAZOLE, HYDROCHLORIDE

CBNumber:: CB6178619

분자식:: C23H26ClN3O3S

포뮬러 무게:: 459.99

MOL 파일:: 130717-51-0.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 33

FR122047염산염 속성

저장 조건: 2-8°C

용해도: 염화메틸렌: 50 mg/m， 약간 흐릿함, 노란색

물리적 상태: 가루

색상: 희미한 노란색

수용성: Soluble to 10 mM in water

안전

안전지침서	22-24/25
WGK 독일	3

FR122047염산염 C화학적 특성, 용도, 생산

개요

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

용도

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

생물학적 활성

Selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 0.028 and 65 μ M for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo .

FR122047염산염 준비 용품 및 원자재

원자재

준비 용품

FR122047염산염 공급 업체

글로벌( 33)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4674	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Suzhou Chenrui Biotechnology Co. LTD	17625585511	1580084073@qq.com	China	677	58

FR122047염산염 관련 검색:

4,5-DIPHENYL-2-METHYLTHIAZOLE 4-(4-METHOXY-PHENYL)-2-METHYL-THIAZOLE 4-PHENYL-THIAZOLE-2-CARBALDEHYDE (4-METHYL-1,3-THIAZOL-2-YL)METHYLAMINE FR 122047 HYDROCHLORIDE N-Methylthiazole-2-methanamine C-(4-PHENYL-THIAZOL-2-YL)-METHYLAMINE 5-Methyl-1,3-thiazole-2-carboxaldehyde 1,3-Thiazole-2-carbaldehyde 1-THIAZOL-2-YLMETHYL-PIPERAZINE 4-METHYL-2-THIAZOLECARBOXALDEHYDE 97 1,3-Thiazole-2-carboxamide 2-AMINOMETHYLTHIAZOLE HYDROCHLORIDE 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYL-PIPERAZINE, MONOHYDROCHLORIDE HYDRATE