ISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE 구조식 이미지
카스 번호:
475-67-2
상품명:
ISOCORYDINE HYDROCHLORIDE
동의어(영문):
luteanin;LUTEANINE;artabotrin;Aids138466;Uzokoridin;Isocorydine;Aids-138466;d-isocorydine;l-(+)-isocorydine;S-ISOCORYDINE (+)
CBNumber:
CB6238999
분자식:
C20H23NO4
포뮬러 무게:
341.4
MOL 파일:
475-67-2.mol

ISOCORYDINE HYDROCHLORIDE 속성

녹는점
216-220 °C(lit.)
알파
D20 +195° (chloroform)
끓는 점
477.03°C (rough estimate)
밀도
1.2064 (rough estimate)
굴절률
1.5614 (estimate)
용해도
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
물리적 상태
Cryst.
산도 계수 (pKa)
9.41±0.20(Predicted)

안전

WGK 독일 3
RTECS 번호 CE1057950
독성 LD50 intraperitoneal in mouse: 104mg/kg

ISOCORYDINE HYDROCHLORIDE C화학적 특성, 용도, 생산

개요

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.

용도

sedative, cholinergic

참고 문헌

See Isocorydine

ISOCORYDINE HYDROCHLORIDE 준비 용품 및 원자재

원자재

준비 용품


ISOCORYDINE HYDROCHLORIDE 공급 업체

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