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PF-04457845

PF-04457845 구조식 이미지

카스 번호:: 1020315-31-4

상품명:: PF-04457845

동의어(영문):: CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-

CBNumber:: CB62522724

분자식:: C23H20F3N5O2

포뮬러 무게:: 455.43

MOL 파일:: 1020315-31-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 72

PF-04457845 속성

끓는 점: 687.0±55.0 °C(Predicted)

밀도: 1.389±0.06 g/cm3(Predicted)

저장 조건: room temp

용해도: DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml

산도 계수 (pKa): 12.72±0.20(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

WGK 독일	3

PF-04457845 C화학적 특성, 용도, 생산

Biochem/physiol Actions

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

PF-04457845 준비 용품 및 원자재

원자재

Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1) Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester CarbaMic acid, N-3-pyridazinyl-, phenyl ester 벤젠메탄올,3-[[5-(트리플루오로메틸)-2-피리디닐]옥시]- Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)- 3-히드록시벤질 알콜 2-클로로-5-(트리플루오로메틸)피리딘

준비 용품

PF-04457845 공급 업체

글로벌( 72)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	10991	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58