ChemicalBook >제품 카탈로그 >시나칼셋아이엠퓨리티8

시나칼셋아이엠퓨리티8

시나칼셋아이엠퓨리티8 구조식 이미지

카스 번호:: 1271930-15-4

한글명:: 시나칼셋아이엠퓨리티8

동의어(한글):: 시나칼셋아이엠퓨리티8

상품명:: Cinacalcet Impurity D

동의어(영문):: Cinacalcet USP RC B;CicalcetImpurity1HCl;CicalcetImpurityDHCl;cinacalcet iMpurity 8;Cinacalcet Impurity D;Cinacalcet Impurity D HCL;Cinacalcet tertiary amine;Cinacalcet USP Related Compound B;Cinacalcet Hydrochloride iMpuritX;Cinacalcet Impurity 5(Cinacalcet USP RC B)

CBNumber:: CB62671079

분자식:: C32H31F6N

포뮬러 무게:: 543.59

MOL 파일:: 1271930-15-4.mol

속성

안전

용도

공급 업체 47

시나칼셋아이엠퓨리티8 속성

끓는 점: 552.2±50.0 °C(Predicted)

밀도: 1.203±0.06 g/cm3(Predicted)

산도 계수 (pKa): 8.40±0.50(Predicted)

InChIKey: BMWNEBVDXWCUKG-CRPMJUFNNA-N

SMILES: C(N([C@@H](C1=C2C(C=CC=C2)=CC=C1)C)CCCC1=CC=CC(C(F)(F)F)=C1)CCC1=CC=CC(C(F)(F)F)=C1 |&1:2,r|

안전

시나칼셋아이엠퓨리티8 C화학적 특성, 용도, 생산

개요

Cinacalcet Impurity D is a potential byproduct or impurity in the synthesis of the drug. It is essential to study the properties and potential implications of Cinacalcet Impurity D for pharmaceutical research. Cinacalcet is a drug commonly used for the treatment of hyperparathyroidism in patients with chronic kidney disease.

용도

N-[(3-Trifluoromethyl)phenyl)propyl] Cinacalcet (Cinacalcet USP Related Compound B) is an impurity of Cinacalcet Hydrochloride (C441800). Cinacalcet is used in clinical trial in secondary hyperparathyroidism.

제조 방법

Cinacalcet hydrochloride (11 g, 0.028 mol) in toluene (150 mL) was added to potassium carbonate (7.74 g, 0.056 mol) followed by 1-(3-bromopropyl)-3-(trifluoromethyl)benzene (14.95 g, 0.056 mol) under stirring at 25-30 °C. The reaction was heated and stirred at 110-111 °C for 48 h. Upon completion of the reaction (by TLC), the reaction was cooled and quenched with water (100 mL). The organic layer was separated, washed with water (100 mL), and concentrated under reduced pressure to obtain a thick oil. The crude oil was then purified by column chromatography on silica gel by eluting with chloroform to afford Cinacalcet Impurity D as a thick transparent oil.

시나칼셋아이엠퓨리티8 준비 용품 및 원자재

원자재

준비 용품

시나칼셋아이엠퓨리티8 공급 업체

글로벌( 47)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18018	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15185	58
Nanjing XiZe Biotechnology CO., Ltd.	025-58362220 15250997978	1511893459@qq.com	China	7774	55
Tonichem Pharmaceutical Technology Co., Ltd.	+86 (0752) 222-7171, +86 15815821171		China	1120	58
Roark Standards	0755-83552066 15986688328	service@roarkstandards.com	China	1443	58

시나칼셋아이엠퓨리티8 관련 검색:

N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propanaMide (αR)-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl)propyl]-1-napthaleneMethanaMine-N-oxide 1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-, hydrochloride (1:1), (αR)- 1-(7,8-dihydronaphthalen-1-yl)ethan-1-amine hydrochloride Cinacalcene Impurity I Cinacalcet impurity C Cinacalcet Impurity 22 N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide Cinacalcet Impurity 21 (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine Cinacalcet IMpurity 6 Cinacalcet IMpurity 3 (E)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)acrylamide Cinacalcet IMpurity 9 (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(M-tolyl)propan-1-aMine N-(1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide 1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethan-1-amine hydrochloride Cinacalcet Impurity H