2,5-디메톡시벤즈알데히드
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2,5-디메톡시벤즈알데히드 속성
- 녹는점
- 46-48 °C (lit.)
- 끓는 점
- 146 °C/10 mmHg (lit.)
- 밀도
- 1.1708 (rough estimate)
- 굴절률
- 1.5260 (estimate)
- 인화점
- >230 °F
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 795mg/l
- 물리적 상태
- 결정질 분말, 결정 및/또는 덩어리
- 색상
- 노란색에서 베이지색
- 수용성
- 클로로포름과 메탄올에 용해됩니다. 물에 약간 용해됩니다.
- 감도
- Air Sensitive
- BRN
- 509301
- InChIKey
- AFUKNJHPZAVHGQ-UHFFFAOYSA-N
- LogP
- 1.910
- CAS 데이터베이스
- 93-02-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-43 | ||
안전지침서 | 26-36/37/39-24/25-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | CU5740500 | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
HS 번호 | 29124900 | ||
기존화학 물질 | KE-11031 |
2,5-디메톡시벤즈알데히드 C화학적 특성, 용도, 생산
용도
의료용 중간체로 사용.보관
실온에서 직사 광선으로부터 멀리하십시오.화학적 성질
yellow crystalline solid![2,5-Dimethoxybenzaldehyde 2,5-Dimethoxybenzaldehyde](https://www.chemicalbook.com/NewsImg/2020-10-14/202010141623961759.png)
용도
2,5-Dimethoxybenzaldehyde is used in the preparation of 2,5-dimethoxyphenethylamine, which is utilized to prepare psychoactive drugs such as 2,5-dimethoxy-4-bromophenethylamine, 2,5-dimethoxy-4-iodophenethylamine and 4-Chloro-2,5-dimethoxy-phenethylamine. It acts as an intermediate in organic synthesis.주요 응용
2,5-Dimethoxybenzaldehyde, also known as 2C-H, is an organic compound and a benzaldehyde derivative. It can be used to produce 2,5-dimethoxyphenethylamine. 2C-H is also used to produce many other substituted phenethylamines such as 2C-B, 2C-I and 2C-C.제조 방법
2,5-Dimethoxybenzaldehyde synthesis: Anethole is oxidized to anisaldehyde , which after isolation is subjected to a BaeyerVilliger oxidation reaction with performic or peracetic acid. The O-formyl-4-methoxyphenol obtained this way is hydrolyzed . 4-Methoxyphenol is subsequently formylated using the Reimer-Tiemann method and the obtained 2-hydroxy-5-methoxybenzaldehyde is methylated with dimethylsulfate to 2,5-dimethoxybenzaldehyde.Reaction
A : Anisaldehyde from anethole via oxidative cleavage: 20 g anise oil was suspended in a mixture of 150 mL water and 30 mL conc. sulfuric acid; addition of 55 g sodium bichromate at such a rate that the temperature did not exceed 40°C. The reaction mixture was extracted with 4 x 125 mL toluene and the solvent evaporated. The residual oil was vacuum distilled to yield 9.1 g anisaldehyde.
B : O-formyl-4-methoxyphenol: 6 mL anisaldehyde was dissolved in 75 mL dichloromethane (DCM). A mixture of 12 g hydrogen peroxide and 10 mL conc. formic acid was added over 30 min. The reaction mixture was gently refluxed for 21 h.
C: B 4-methoxyphenol: Evaporating the solvent from reaction mixture and taking up the residue in 100 mL aqueous NaOH (20%) (25 mL MeOH as co-solvent) yielded 4.1 g 4-methoxyphenol as a white crystalline product after the usual work-up and purification steps.
D : Reimer-Tiemann formylation of 4-methoxyphenol: 124.1 g 4-methoxyphenol was dissolved in NaOH solution (320 g NaOH in 400 mL water). In total, 161 mL chloroform was added. The usual work-up and steam distillation yielded 109.8 g of a clear yellow oil that did not solidify upon standing at room temperature (GC/MS: 94% 2-hydroxy-5-methoxybenzaldehyde).
E: D Methylation of 2-hydroxy-5-methoxybenzaldehyde: The yellow oil from was used without further purification. A 250 mL RB flask was charged with 100 mL acetone, 14 g anhydrous potassium carbonate and 10 g 2-hydroxy-5-methoxybenzaldehyde; the mixture was brought at reflux temperature and 11 g dimethyl sulfate was added. The reaction was continued for 4 hours. The solvent is evaporated and the crude end product crystallized in cold water. Recrystallization from EtOH/water yielded 8.3 g 2,5-dimethoxybenzaldehyde (GC/MS: 98%+ 2,5-dimethoxybenzaldehyde)
2,5-디메톡시벤즈알데히드 준비 용품 및 원자재
원자재
준비 용품
2,5-디메톡시벤질아민
1-(2 5-DIMETHOXYPHENYL)-2-AMINOPROPANE&
4-IODO-2,5-다이메톡시페네틸아민
2,5-DIMETHOXYBENZYL ALCOHOL
2-아미노-1-(2,5-디메톡시페닐)에탄올
47-디메톡시-1-인다논97
4-브로모-2,5-디메톡시벤즈알데히드
2,5-Dimethoxycinnamic acid
2-(2,5-Dimethoxy-phenyl)-benzothiazole
3-[(5Z)-5-[(2,5-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoic acid
2,5-디메톡시-베타-니트로스타이렌
2,5-디메톡시벤즈알데히드 공급 업체
글로벌( 638)공급 업체
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Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 |
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