2,5-디메톡시벤즈알데히드

2,5-디메톡시벤즈알데히드
2,5-디메톡시벤즈알데히드 구조식 이미지
카스 번호:
93-02-7
한글명:
2,5-디메톡시벤즈알데히드
동의어(한글):
2,5-디메톡시벤즈알데하이드;2,5-디메톡시벤즈알데히드
상품명:
2,5-Dimethoxybenzaldehyde
동의어(영문):
Benzaldehyde, 2,5-dimethoxy-;34007;93-02--7;Benzaldehyde CRS;2,5-DiMethoxybenzaldehyde, 97% 25GR;NSC 6315;AKOS BBS-00003162;2,5-DimethoxybenzaL;2,5-Dimethoxybenzald;5-DiMethoxy benzaldehyde
CBNumber:
CB6348890
분자식:
C9H10O3
포뮬러 무게:
166.17
MOL 파일:
93-02-7.mol
MSDS 파일:
SDS

2,5-디메톡시벤즈알데히드 속성

녹는점
46-48 °C (lit.)
끓는 점
146 °C/10 mmHg (lit.)
밀도
1.1708 (rough estimate)
굴절률
1.5260 (estimate)
인화점
>230 °F
저장 조건
Keep in dark place,Sealed in dry,Room Temperature
용해도
795mg/l
물리적 상태
결정질 분말, 결정 및/또는 덩어리
색상
노란색에서 베이지색
수용성
클로로포름과 메탄올에 용해됩니다. 물에 약간 용해됩니다.
감도
Air Sensitive
BRN
509301
InChIKey
AFUKNJHPZAVHGQ-UHFFFAOYSA-N
LogP
1.910
CAS 데이터베이스
93-02-7(CAS DataBase Reference)
NIST
Benzaldehyde, 2,5-dimethoxy-(93-02-7)
EPA
Benzaldehyde, 2,5-dimethoxy- (93-02-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38-43
안전지침서 26-36/37/39-24/25-36
WGK 독일 2
RTECS 번호 CU5740500
위험 참고 사항 Irritant
TSCA Yes
HS 번호 29124900
기존화학 물질 KE-11031
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음 호흡기 과민성 물질 구분 1 위험 GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P271 옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
1
2 0

2,5-디메톡시벤즈알데히드 MSDS


2,5-Dimethoxybenzaldehyde

2,5-디메톡시벤즈알데히드 C화학적 특성, 용도, 생산

용도

의료용 중간체로 사용.

보관

실온에서 직사 광선으로부터 멀리하십시오.

화학적 성질

yellow crystalline solid
2,5-Dimethoxybenzaldehyde

용도

2,5-Dimethoxybenzaldehyde is used in the preparation of 2,5-dimethoxyphenethylamine, which is utilized to prepare psychoactive drugs such as 2,5-dimethoxy-4-bromophenethylamine, 2,5-dimethoxy-4-iodophenethylamine and 4-Chloro-2,5-dimethoxy-phenethylamine. It acts as an intermediate in organic synthesis.

주요 응용

2,5-Dimethoxybenzaldehyde, also known as 2C-H, is an organic compound and a benzaldehyde derivative. It can be used to produce 2,5-dimethoxyphenethylamine. 2C-H is also used to produce many other substituted phenethylamines such as 2C-B, 2C-I and 2C-C.

제조 방법

2,5-Dimethoxybenzaldehyde synthesis: Anethole is oxidized to anisaldehyde , which after isolation is subjected to a BaeyerVilliger oxidation reaction with performic or peracetic acid. The O-formyl-4-methoxyphenol obtained this way is hydrolyzed . 4-Methoxyphenol is subsequently formylated using the Reimer-Tiemann method and the obtained 2-hydroxy-5-methoxybenzaldehyde is methylated with dimethylsulfate to 2,5-dimethoxybenzaldehyde.
Reaction
A : Anisaldehyde from anethole via oxidative cleavage: 20 g anise oil was suspended in a mixture of 150 mL water and 30 mL conc. sulfuric acid; addition of 55 g sodium bichromate at such a rate that the temperature did not exceed 40°C. The reaction mixture was extracted with 4 x 125 mL toluene and the solvent evaporated. The residual oil was vacuum distilled to yield 9.1 g anisaldehyde.
B : O-formyl-4-methoxyphenol: 6 mL anisaldehyde was dissolved in 75 mL dichloromethane (DCM). A mixture of 12 g hydrogen peroxide and 10 mL conc. formic acid was added over 30 min. The reaction mixture was gently refluxed for 21 h.
C: B 4-methoxyphenol: Evaporating the solvent from reaction mixture and taking up the residue in 100 mL aqueous NaOH (20%) (25 mL MeOH as co-solvent) yielded 4.1 g 4-methoxyphenol as a white crystalline product after the usual work-up and purification steps.
D : Reimer-Tiemann formylation of 4-methoxyphenol: 124.1 g 4-methoxyphenol was dissolved in NaOH solution (320 g NaOH in 400 mL water). In total, 161 mL chloroform was added. The usual work-up and steam distillation yielded 109.8 g of a clear yellow oil that did not solidify upon standing at room temperature (GC/MS: 94% 2-hydroxy-5-methoxybenzaldehyde).
E: D Methylation of 2-hydroxy-5-methoxybenzaldehyde: The yellow oil from was used without further purification. A 250 mL RB flask was charged with 100 mL acetone, 14 g anhydrous potassium carbonate and 10 g 2-hydroxy-5-methoxybenzaldehyde; the mixture was brought at reflux temperature and 11 g dimethyl sulfate was added. The reaction was continued for 4 hours. The solvent is evaporated and the crude end product crystallized in cold water. Recrystallization from EtOH/water yielded 8.3 g 2,5-dimethoxybenzaldehyde (GC/MS: 98%+ 2,5-dimethoxybenzaldehyde)

2,5-디메톡시벤즈알데히드 준비 용품 및 원자재

원자재

준비 용품


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